A randomized phase I study of methanesulfonyl fluoride, an irreversible cholinesterase inhibitor, for the treatment of Alzheimer's disease

AIMS: To ascertain the tolerability profile of single and repeated oral doses of methanesulfonyl fluoride (MSF, SNX-001) in healthy aged subjects, and to determine the degree of erythrocyte acetylcholinesterase (AChE) inhibition induced by MSF after single and repeated oral doses. METHODS: To calcul...

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Detalles Bibliográficos
Autores principales: Moss, Donald E, Fariello, Ruggero G, Sahlmann, Jörg, Sumaya, Isabel, Pericle, Federica, Braglia, Enrico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Science Inc 2013
Materias:
Translational Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635594/
https://www.ncbi.nlm.nih.gov/pubmed/23116458
http://dx.doi.org/10.1111/bcp.12018

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635594/
https://www.ncbi.nlm.nih.gov/pubmed/23116458
http://dx.doi.org/10.1111/bcp.12018

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