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Primary Central Nervous System ALK Positive Anaplastic Large Cell Lymphoma with Predominantly Leptomeningeal Involvement in an Adult

A 31-year-old Korean male presented with altered consciousness and severe headache. Brain MRI delineated focal leptomeningeal enhancement without any intracerebral lesions. Diagnosis was made based on a brain biopsy showing anaplastic large cell lymphoma (ALCL), immunohistochemical stains revealing...

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Autores principales: Park, Jae Sung, Park, Heejung, Park, Sanghui, Kim, Suk Jin, Seol, Ho Jun, Ko, Young-Hyeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Yonsei University College of Medicine 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635648/
https://www.ncbi.nlm.nih.gov/pubmed/23549832
http://dx.doi.org/10.3349/ymj.2013.54.3.791
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author Park, Jae Sung
Park, Heejung
Park, Sanghui
Kim, Suk Jin
Seol, Ho Jun
Ko, Young-Hyeh
author_facet Park, Jae Sung
Park, Heejung
Park, Sanghui
Kim, Suk Jin
Seol, Ho Jun
Ko, Young-Hyeh
author_sort Park, Jae Sung
collection PubMed
description A 31-year-old Korean male presented with altered consciousness and severe headache. Brain MRI delineated focal leptomeningeal enhancement without any intracerebral lesions. Diagnosis was made based on a brain biopsy showing anaplastic large cell lymphoma (ALCL), immunohistochemical stains revealing positivity for anaplastic lymphoma kinase (ALK) and an absence of involvement in any other organs; specifically, the primary central nervous system ALK+ALCL. Complete remission was achieved following 5 cycles of systemic chemotherapy with a high dose of Methotrexate and a simultaneous 7 cycles of intrathecal triple chemotherapy. Diagnosis of primary leptomeningeal ALK+ALCL is challenging given its rarity and non-specific symptoms along with non-pathognomonic radiologic findings. We present the first case of primary leptomeningeal ALK-positive ALCL where the clinical course, pathologic characteristics and treatment modality are described as well as a review of literature.
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spelling pubmed-36356482013-05-02 Primary Central Nervous System ALK Positive Anaplastic Large Cell Lymphoma with Predominantly Leptomeningeal Involvement in an Adult Park, Jae Sung Park, Heejung Park, Sanghui Kim, Suk Jin Seol, Ho Jun Ko, Young-Hyeh Yonsei Med J Case Report A 31-year-old Korean male presented with altered consciousness and severe headache. Brain MRI delineated focal leptomeningeal enhancement without any intracerebral lesions. Diagnosis was made based on a brain biopsy showing anaplastic large cell lymphoma (ALCL), immunohistochemical stains revealing positivity for anaplastic lymphoma kinase (ALK) and an absence of involvement in any other organs; specifically, the primary central nervous system ALK+ALCL. Complete remission was achieved following 5 cycles of systemic chemotherapy with a high dose of Methotrexate and a simultaneous 7 cycles of intrathecal triple chemotherapy. Diagnosis of primary leptomeningeal ALK+ALCL is challenging given its rarity and non-specific symptoms along with non-pathognomonic radiologic findings. We present the first case of primary leptomeningeal ALK-positive ALCL where the clinical course, pathologic characteristics and treatment modality are described as well as a review of literature. Yonsei University College of Medicine 2013-05-01 2013-03-19 /pmc/articles/PMC3635648/ /pubmed/23549832 http://dx.doi.org/10.3349/ymj.2013.54.3.791 Text en © Copyright: Yonsei University College of Medicine 2013 http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Park, Jae Sung
Park, Heejung
Park, Sanghui
Kim, Suk Jin
Seol, Ho Jun
Ko, Young-Hyeh
Primary Central Nervous System ALK Positive Anaplastic Large Cell Lymphoma with Predominantly Leptomeningeal Involvement in an Adult
title Primary Central Nervous System ALK Positive Anaplastic Large Cell Lymphoma with Predominantly Leptomeningeal Involvement in an Adult
title_full Primary Central Nervous System ALK Positive Anaplastic Large Cell Lymphoma with Predominantly Leptomeningeal Involvement in an Adult
title_fullStr Primary Central Nervous System ALK Positive Anaplastic Large Cell Lymphoma with Predominantly Leptomeningeal Involvement in an Adult
title_full_unstemmed Primary Central Nervous System ALK Positive Anaplastic Large Cell Lymphoma with Predominantly Leptomeningeal Involvement in an Adult
title_short Primary Central Nervous System ALK Positive Anaplastic Large Cell Lymphoma with Predominantly Leptomeningeal Involvement in an Adult
title_sort primary central nervous system alk positive anaplastic large cell lymphoma with predominantly leptomeningeal involvement in an adult
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635648/
https://www.ncbi.nlm.nih.gov/pubmed/23549832
http://dx.doi.org/10.3349/ymj.2013.54.3.791
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