Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells

BACKGROUND: Temozolomide (TMZ) is the most widely used drug to treat glioblastoma (GBM), which is the most common and aggressive primary tumor of the Central Nervous System and one of the hardest challenges in oncotherapy. TMZ is an alkylating agent that induces autophagy, apoptosis and senescence i...

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Detalles Bibliográficos
Autores principales: Filippi-Chiela, Eduardo C, Thomé, Marcos Paulo, Bueno e Silva, Mardja Manssur, Pelegrini, Alessandra Luíza, Ledur, Pitia Flores, Garicochea, Bernardo, Zamin, Lauren L, Lenz, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635906/
https://www.ncbi.nlm.nih.gov/pubmed/23522185
http://dx.doi.org/10.1186/1471-2407-13-147

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