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Regulatory T Cells Negatively Affect IL-2 Production of Effector T Cells through CD39/Adenosine Pathway in HIV Infection

The mechanisms by which Regulatory T cells suppress IL-2 production of effector CD4+ T cells in pathological conditions are unclear. A subpopulation of human Treg expresses the ectoenzyme CD39, which in association with CD73 converts ATP/ADP/AMP to adenosine. We show here that Treg/CD39+ suppress IL...

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Detalles Bibliográficos
Autores principales:	Jenabian, Mohammad-Ali, Seddiki, Nabila, Yatim, Ahmad, Carriere, Matthieu, Hulin, Anne, Younas, Mehwish, Ghadimi, Elnaz, Kök, Ayrin, Routy, Jean-Pierre, Tremblay, Alain, Sévigny, Jean, Lelievre, Jean-Daniel, Levy, Yves
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635970/ https://www.ncbi.nlm.nih.gov/pubmed/23658513 http://dx.doi.org/10.1371/journal.ppat.1003319

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