Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against Toxoplasma gondii

IFN-γ activates cells to restrict intracellular pathogens by upregulating cellular effectors including the p65 family of guanylate-binding proteins (GBPs). Here we test the role of Gbp1 in the IFN-γ-dependent control of T. gondii in the mouse model. Virulent strains of T. gondii avoided recruitment...

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Detalles Bibliográficos
Autores principales: Selleck, Elizabeth M., Fentress, Sarah J., Beatty, Wandy L., Degrandi, Daniel, Pfeffer, Klaus, Virgin, Herbert W., MacMicking, John D., Sibley, L. David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635975/
https://www.ncbi.nlm.nih.gov/pubmed/23633952
http://dx.doi.org/10.1371/journal.ppat.1003320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635975/
https://www.ncbi.nlm.nih.gov/pubmed/23633952
http://dx.doi.org/10.1371/journal.ppat.1003320

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