Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity

The RIG-I like receptor pathway is stimulated during RNA virus infection by interaction between cytosolic RIG-I and viral RNA structures that contain short hairpin dsRNA and 5′ triphosphate (5′ppp) terminal structure. In the present study, an RNA agonist of RIG-I was synthesized in vitro and shown t...

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Detalles Bibliográficos
Autores principales: Goulet, Marie-Line, Olagnier, David, Xu, Zhengyun, Paz, Suzanne, Belgnaoui, S. Mehdi, Lafferty, Erin I., Janelle, Valérie, Arguello, Meztli, Paquet, Marilene, Ghneim, Khader, Richards, Stephanie, Smith, Andrew, Wilkinson, Peter, Cameron, Mark, Kalinke, Ulrich, Qureshi, Salman, Lamarre, Alain, Haddad, Elias K., Sekaly, Rafick Pierre, Peri, Suraj, Balachandran, Siddharth, Lin, Rongtuan, Hiscott, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635991/
https://www.ncbi.nlm.nih.gov/pubmed/23633948
http://dx.doi.org/10.1371/journal.ppat.1003298

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