Fragile X mental retardation protein and synaptic plasticity

Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a trans...

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Detalles Bibliográficos
Autores principales: Sidorov, Michael S, Auerbach, Benjamin D, Bear, Mark F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636002/
https://www.ncbi.nlm.nih.gov/pubmed/23566911
http://dx.doi.org/10.1186/1756-6606-6-15
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author Sidorov, Michael S
Auerbach, Benjamin D
Bear, Mark F
author_facet Sidorov, Michael S
Auerbach, Benjamin D
Bear, Mark F
author_sort Sidorov, Michael S
collection PubMed
description Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity.
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spelling pubmed-36360022013-04-26 Fragile X mental retardation protein and synaptic plasticity Sidorov, Michael S Auerbach, Benjamin D Bear, Mark F Mol Brain Review Loss of the translational repressor FMRP causes Fragile X syndrome. In healthy neurons, FMRP modulates the local translation of numerous synaptic proteins. Synthesis of these proteins is required for the maintenance and regulation of long-lasting changes in synaptic strength. In this role as a translational inhibitor, FMRP exerts profound effects on synaptic plasticity. BioMed Central 2013-04-08 /pmc/articles/PMC3636002/ /pubmed/23566911 http://dx.doi.org/10.1186/1756-6606-6-15 Text en Copyright © 2013 Sidorov et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Sidorov, Michael S
Auerbach, Benjamin D
Bear, Mark F
Fragile X mental retardation protein and synaptic plasticity
title Fragile X mental retardation protein and synaptic plasticity
title_full Fragile X mental retardation protein and synaptic plasticity
title_fullStr Fragile X mental retardation protein and synaptic plasticity
title_full_unstemmed Fragile X mental retardation protein and synaptic plasticity
title_short Fragile X mental retardation protein and synaptic plasticity
title_sort fragile x mental retardation protein and synaptic plasticity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636002/
https://www.ncbi.nlm.nih.gov/pubmed/23566911
http://dx.doi.org/10.1186/1756-6606-6-15
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