Sulfated Polysaccharide, Curdlan Sulfate, Efficiently Prevents Entry/Fusion and Restricts Antibody-Dependent Enhancement of Dengue Virus Infection In Vitro: A Possible Candidate for Clinical Application

Curdlan sulfate (CRDS), a sulfated 1→3-β-D glucan, previously shown to be a potent HIV entry inhibitor, is characterized in this study as a potent inhibitor of the Dengue virus (DENV). CRDS was identified by in silico blind docking studies to exhibit binding potential to the envelope (E) protein of...

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Detalles Bibliográficos
Autores principales: Ichiyama, Koji, Gopala Reddy, Sindhoora Bhargavi, Zhang, Li Feng, Chin, Wei Xin, Muschin, Tegshi, Heinig, Lars, Suzuki, Youichi, Nanjundappa, Haraprasad, Yoshinaka, Yoshiyuki, Ryo, Akihide, Nomura, Nobuo, Ooi, Eng Eong, Vasudevan, Subhash G., Yoshida, Takashi, Yamamoto, Naoki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636050/
https://www.ncbi.nlm.nih.gov/pubmed/23658845
http://dx.doi.org/10.1371/journal.pntd.0002188

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