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Signatures of Diversifying Selection in European Pig Breeds

Following domestication, livestock breeds have experienced intense selection pressures for the development of desirable traits. This has resulted in a large diversity of breeds that display variation in many phenotypic traits, such as coat colour, muscle composition, early maturity, growth rate, bod...

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Autores principales: Wilkinson, Samantha, Lu, Zen H., Megens, Hendrik-Jan, Archibald, Alan L., Haley, Chris, Jackson, Ian J., Groenen, Martien A. M., Crooijmans, Richard P. M. A., Ogden, Rob, Wiener, Pamela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636142/
https://www.ncbi.nlm.nih.gov/pubmed/23637623
http://dx.doi.org/10.1371/journal.pgen.1003453
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author Wilkinson, Samantha
Lu, Zen H.
Megens, Hendrik-Jan
Archibald, Alan L.
Haley, Chris
Jackson, Ian J.
Groenen, Martien A. M.
Crooijmans, Richard P. M. A.
Ogden, Rob
Wiener, Pamela
author_facet Wilkinson, Samantha
Lu, Zen H.
Megens, Hendrik-Jan
Archibald, Alan L.
Haley, Chris
Jackson, Ian J.
Groenen, Martien A. M.
Crooijmans, Richard P. M. A.
Ogden, Rob
Wiener, Pamela
author_sort Wilkinson, Samantha
collection PubMed
description Following domestication, livestock breeds have experienced intense selection pressures for the development of desirable traits. This has resulted in a large diversity of breeds that display variation in many phenotypic traits, such as coat colour, muscle composition, early maturity, growth rate, body size, reproduction, and behaviour. To better understand the relationship between genomic composition and phenotypic diversity arising from breed development, the genomes of 13 traditional and commercial European pig breeds were scanned for signatures of diversifying selection using the Porcine60K SNP chip, applying a between-population (differentiation) approach. Signatures of diversifying selection between breeds were found in genomic regions associated with traits related to breed standard criteria, such as coat colour and ear morphology. Amino acid differences in the EDNRB gene appear to be associated with one of these signatures, and variation in the KITLG gene may be associated with another. Other selection signals were found in genomic regions including QTLs and genes associated with production traits such as reproduction, growth, and fat deposition. Some selection signatures were associated with regions showing evidence of introgression from Asian breeds. When the European breeds were compared with wild boar, genomic regions with high levels of differentiation harboured genes related to bone formation, growth, and fat deposition.
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spelling pubmed-36361422013-05-01 Signatures of Diversifying Selection in European Pig Breeds Wilkinson, Samantha Lu, Zen H. Megens, Hendrik-Jan Archibald, Alan L. Haley, Chris Jackson, Ian J. Groenen, Martien A. M. Crooijmans, Richard P. M. A. Ogden, Rob Wiener, Pamela PLoS Genet Research Article Following domestication, livestock breeds have experienced intense selection pressures for the development of desirable traits. This has resulted in a large diversity of breeds that display variation in many phenotypic traits, such as coat colour, muscle composition, early maturity, growth rate, body size, reproduction, and behaviour. To better understand the relationship between genomic composition and phenotypic diversity arising from breed development, the genomes of 13 traditional and commercial European pig breeds were scanned for signatures of diversifying selection using the Porcine60K SNP chip, applying a between-population (differentiation) approach. Signatures of diversifying selection between breeds were found in genomic regions associated with traits related to breed standard criteria, such as coat colour and ear morphology. Amino acid differences in the EDNRB gene appear to be associated with one of these signatures, and variation in the KITLG gene may be associated with another. Other selection signals were found in genomic regions including QTLs and genes associated with production traits such as reproduction, growth, and fat deposition. Some selection signatures were associated with regions showing evidence of introgression from Asian breeds. When the European breeds were compared with wild boar, genomic regions with high levels of differentiation harboured genes related to bone formation, growth, and fat deposition. Public Library of Science 2013-04-25 /pmc/articles/PMC3636142/ /pubmed/23637623 http://dx.doi.org/10.1371/journal.pgen.1003453 Text en © 2013 Wilkinson et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Wilkinson, Samantha
Lu, Zen H.
Megens, Hendrik-Jan
Archibald, Alan L.
Haley, Chris
Jackson, Ian J.
Groenen, Martien A. M.
Crooijmans, Richard P. M. A.
Ogden, Rob
Wiener, Pamela
Signatures of Diversifying Selection in European Pig Breeds
title Signatures of Diversifying Selection in European Pig Breeds
title_full Signatures of Diversifying Selection in European Pig Breeds
title_fullStr Signatures of Diversifying Selection in European Pig Breeds
title_full_unstemmed Signatures of Diversifying Selection in European Pig Breeds
title_short Signatures of Diversifying Selection in European Pig Breeds
title_sort signatures of diversifying selection in european pig breeds
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636142/
https://www.ncbi.nlm.nih.gov/pubmed/23637623
http://dx.doi.org/10.1371/journal.pgen.1003453
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