Molecular Modeling Study for Inhibition Mechanism of Human Chymase and Its Application in Inhibitor Design

Human chymase catalyzes the hydrolysis of peptide bonds. Three chymase inhibitors with very similar chemical structures but highly different inhibitory profiles towards the hydrolase function of chymase were selected with the aim of elucidating the origin of disparities in their biological activitie...

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Detalles Bibliográficos
Autores principales: Arooj, Mahreen, Kim, Songmi, Sakkiah, Sugunadevi, Cao, Guang Ping, Lee, Yuno, Lee, Keun Woo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636146/
https://www.ncbi.nlm.nih.gov/pubmed/23638140
http://dx.doi.org/10.1371/journal.pone.0062740

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636146/
https://www.ncbi.nlm.nih.gov/pubmed/23638140
http://dx.doi.org/10.1371/journal.pone.0062740

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