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Molecular Modeling Study for Inhibition Mechanism of Human Chymase and Its Application in Inhibitor Design
Human chymase catalyzes the hydrolysis of peptide bonds. Three chymase inhibitors with very similar chemical structures but highly different inhibitory profiles towards the hydrolase function of chymase were selected with the aim of elucidating the origin of disparities in their biological activitie...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636146/ https://www.ncbi.nlm.nih.gov/pubmed/23638140 http://dx.doi.org/10.1371/journal.pone.0062740 |