Principles of dose finding studies in cancer: a comparison of trial designs

PURPOSE: One key aim of Phase I cancer studies is to identify the dose of a treatment to be further evaluated in Phase II. We describe, in non-statistical language, three classes of dose-escalation trial design and compare their properties. METHODS: We review three classes of dose-escalation design...

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Detalles Bibliográficos
Autores principales: Jaki, Thomas, Clive, Sally, Weir, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636432/
https://www.ncbi.nlm.nih.gov/pubmed/23299793
http://dx.doi.org/10.1007/s00280-012-2059-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636432/
https://www.ncbi.nlm.nih.gov/pubmed/23299793
http://dx.doi.org/10.1007/s00280-012-2059-8

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