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Principles of dose finding studies in cancer: a comparison of trial designs
PURPOSE: One key aim of Phase I cancer studies is to identify the dose of a treatment to be further evaluated in Phase II. We describe, in non-statistical language, three classes of dose-escalation trial design and compare their properties. METHODS: We review three classes of dose-escalation design...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636432/ https://www.ncbi.nlm.nih.gov/pubmed/23299793 http://dx.doi.org/10.1007/s00280-012-2059-8 |