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Saccharomyces cerevisiae as a Model to Study Replicative Senescence Triggered by Telomere Shortening
In many somatic human tissues, telomeres shorten progressively because of the DNA-end replication problem. Consequently, cells cease to proliferate and are maintained in a metabolically viable state called replicative senescence. These cells are characterized by an activation of DNA damage checkpoin...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Frontiers Media S.A.
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636481/ https://www.ncbi.nlm.nih.gov/pubmed/23638436 http://dx.doi.org/10.3389/fonc.2013.00101 |