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Astroglial networking contributes to neurometabolic coupling

The strategic position of astrocytic processes between blood capillaries and neurons, provided the early insight that astrocytes play a key role in supplying energy substrates to neurons in an activity-dependent manner. The central role of astrocytes in neurometabolic coupling has been first establi...

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Detalles Bibliográficos
Autores principales: Escartin, Carole, Rouach, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636502/
https://www.ncbi.nlm.nih.gov/pubmed/23637659
http://dx.doi.org/10.3389/fnene.2013.00004
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author Escartin, Carole
Rouach, Nathalie
author_facet Escartin, Carole
Rouach, Nathalie
author_sort Escartin, Carole
collection PubMed
description The strategic position of astrocytic processes between blood capillaries and neurons, provided the early insight that astrocytes play a key role in supplying energy substrates to neurons in an activity-dependent manner. The central role of astrocytes in neurometabolic coupling has been first established at the level of single cell. Since then, exciting recent work based on cellular imaging and electrophysiological recordings has provided new mechanistic insights into this phenomenon, revealing the crucial role of gap junction (GJ)-mediated networks of astrocytes. Indeed, astrocytes define the local availability of energy substrates by regulating blood flow. Subsequently, in order to efficiently reach distal neurons, these substrates can be taken up, and distributed through networks of astrocytes connected by GJs, a process modulated by neuronal activity. Astrocytic networks can be morphologically and/or functionally altered in the course of various pathological conditions, raising the intriguing possibility of a direct contribution from these networks to neuronal dysfunction. The present review upgrades the current view of neuroglial metabolic coupling, by including the recently unravelled properties of astroglial metabolic networks and their potential contribution to normal and pathological neuronal activity.
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spelling pubmed-36365022013-05-01 Astroglial networking contributes to neurometabolic coupling Escartin, Carole Rouach, Nathalie Front Neuroenergetics Neuroscience The strategic position of astrocytic processes between blood capillaries and neurons, provided the early insight that astrocytes play a key role in supplying energy substrates to neurons in an activity-dependent manner. The central role of astrocytes in neurometabolic coupling has been first established at the level of single cell. Since then, exciting recent work based on cellular imaging and electrophysiological recordings has provided new mechanistic insights into this phenomenon, revealing the crucial role of gap junction (GJ)-mediated networks of astrocytes. Indeed, astrocytes define the local availability of energy substrates by regulating blood flow. Subsequently, in order to efficiently reach distal neurons, these substrates can be taken up, and distributed through networks of astrocytes connected by GJs, a process modulated by neuronal activity. Astrocytic networks can be morphologically and/or functionally altered in the course of various pathological conditions, raising the intriguing possibility of a direct contribution from these networks to neuronal dysfunction. The present review upgrades the current view of neuroglial metabolic coupling, by including the recently unravelled properties of astroglial metabolic networks and their potential contribution to normal and pathological neuronal activity. Frontiers Media S.A. 2013-04-26 /pmc/articles/PMC3636502/ /pubmed/23637659 http://dx.doi.org/10.3389/fnene.2013.00004 Text en Copyright © 2013 Escartin and Rouach. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Neuroscience
Escartin, Carole
Rouach, Nathalie
Astroglial networking contributes to neurometabolic coupling
title Astroglial networking contributes to neurometabolic coupling
title_full Astroglial networking contributes to neurometabolic coupling
title_fullStr Astroglial networking contributes to neurometabolic coupling
title_full_unstemmed Astroglial networking contributes to neurometabolic coupling
title_short Astroglial networking contributes to neurometabolic coupling
title_sort astroglial networking contributes to neurometabolic coupling
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636502/
https://www.ncbi.nlm.nih.gov/pubmed/23637659
http://dx.doi.org/10.3389/fnene.2013.00004
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