Secondary Membranous Nephropathy Associated with Guillain-Barré Syndrome

Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome (NS) in adults. It may be primary, usually mediated by IgG4 anti-phospholipase A2 autoantibodies or secondary to various other conditions. Guillain- Barré syndrome (GBS) has been associated with MN, but a cause and ef...

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Detalles Bibliográficos
Autores principales: J. Filippone, Edward, Kanzaria, Mitul, Bell, Rodney, Newman, Eric, L. Farber, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2013
Materias:
Published online: April, 2013
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636961/
https://www.ncbi.nlm.nih.gov/pubmed/23626596
http://dx.doi.org/10.1159/000350903
Descripción
Sumario:Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome (NS) in adults. It may be primary, usually mediated by IgG4 anti-phospholipase A2 autoantibodies or secondary to various other conditions. Guillain- Barré syndrome (GBS) has been associated with MN, but a cause and effect relation has not been proven. We present a case of concurrent development of GBS and severe NS, with renal biopsy demonstrating MN. IgG4 stain was negative, indicating that most likely, the MN was secondary and probably caused by the underlying GBS.

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