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Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice

BACKGROUNDS: Solid evidence has demonstrated that psychoemotional stress induced alteration of hair cycle through neuropeptide substance P (SP) mediated immune response, the role of reactive oxygen species (ROS) in brain-skin-axis regulation system remains unknown. OBJECTIVES: The present study aims...

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Autores principales: Liu, Nan, Wang, Lin-Hui, Guo, Ling-Ling, Wang, Guo-Qing, Zhou, Xi-Ping, Jiang, Yan, Shang, Jing, Murao, Koji, Chen, Jing-Wei, Fu, Wen-Qing, Zhang, Guo-Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637209/
https://www.ncbi.nlm.nih.gov/pubmed/23637859
http://dx.doi.org/10.1371/journal.pone.0061574
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author Liu, Nan
Wang, Lin-Hui
Guo, Ling-Ling
Wang, Guo-Qing
Zhou, Xi-Ping
Jiang, Yan
Shang, Jing
Murao, Koji
Chen, Jing-Wei
Fu, Wen-Qing
Zhang, Guo-Xing
author_facet Liu, Nan
Wang, Lin-Hui
Guo, Ling-Ling
Wang, Guo-Qing
Zhou, Xi-Ping
Jiang, Yan
Shang, Jing
Murao, Koji
Chen, Jing-Wei
Fu, Wen-Qing
Zhang, Guo-Xing
author_sort Liu, Nan
collection PubMed
description BACKGROUNDS: Solid evidence has demonstrated that psychoemotional stress induced alteration of hair cycle through neuropeptide substance P (SP) mediated immune response, the role of reactive oxygen species (ROS) in brain-skin-axis regulation system remains unknown. OBJECTIVES: The present study aims to investigate possible mechanisms of ROS in regulation of SP-mast cell signal pathway in chronic restraint stress (CRS, a model of chronic psychoemotional stress) which induced abnormal of hair cycle. METHODS AND RESULTS: Our results have demonstrated that CRS actually altered hair cycle by inhibiting hair follicle growth in vivo, prolonging the telogen stage and delaying subsequent anagen and catagen stage. Up-regulation of SP protein expression in cutaneous peripheral nerve fibers and activation of mast cell were observed accompanied with increase of lipid peroxidation levels and reduction of the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in CRS mice skin. In addition, SP receptor antagonist (RP67580) reduced mast cell activations and lipid peroxidation levels as well as increased GSH-Px activity and normalized hair cycle. Furthermore, antioxidant Tempol (a free radical scavenger) also restored hair cycle, reduced SP protein expression and mast cell activation. CONCLUSIONS: Our study provides the first solid evidence for how ROS play a role in regulation of psychoemotional stress induced SP-Mast cell pathway which may provide a convincing rationale for antioxidant application in clinical treatment with psychological stress induced hair loss.
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spelling pubmed-36372092013-05-01 Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice Liu, Nan Wang, Lin-Hui Guo, Ling-Ling Wang, Guo-Qing Zhou, Xi-Ping Jiang, Yan Shang, Jing Murao, Koji Chen, Jing-Wei Fu, Wen-Qing Zhang, Guo-Xing PLoS One Research Article BACKGROUNDS: Solid evidence has demonstrated that psychoemotional stress induced alteration of hair cycle through neuropeptide substance P (SP) mediated immune response, the role of reactive oxygen species (ROS) in brain-skin-axis regulation system remains unknown. OBJECTIVES: The present study aims to investigate possible mechanisms of ROS in regulation of SP-mast cell signal pathway in chronic restraint stress (CRS, a model of chronic psychoemotional stress) which induced abnormal of hair cycle. METHODS AND RESULTS: Our results have demonstrated that CRS actually altered hair cycle by inhibiting hair follicle growth in vivo, prolonging the telogen stage and delaying subsequent anagen and catagen stage. Up-regulation of SP protein expression in cutaneous peripheral nerve fibers and activation of mast cell were observed accompanied with increase of lipid peroxidation levels and reduction of the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in CRS mice skin. In addition, SP receptor antagonist (RP67580) reduced mast cell activations and lipid peroxidation levels as well as increased GSH-Px activity and normalized hair cycle. Furthermore, antioxidant Tempol (a free radical scavenger) also restored hair cycle, reduced SP protein expression and mast cell activation. CONCLUSIONS: Our study provides the first solid evidence for how ROS play a role in regulation of psychoemotional stress induced SP-Mast cell pathway which may provide a convincing rationale for antioxidant application in clinical treatment with psychological stress induced hair loss. Public Library of Science 2013-04-26 /pmc/articles/PMC3637209/ /pubmed/23637859 http://dx.doi.org/10.1371/journal.pone.0061574 Text en © 2013 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Liu, Nan
Wang, Lin-Hui
Guo, Ling-Ling
Wang, Guo-Qing
Zhou, Xi-Ping
Jiang, Yan
Shang, Jing
Murao, Koji
Chen, Jing-Wei
Fu, Wen-Qing
Zhang, Guo-Xing
Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice
title Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice
title_full Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice
title_fullStr Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice
title_full_unstemmed Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice
title_short Chronic Restraint Stress Inhibits Hair Growth via Substance P Mediated by Reactive Oxygen Species in Mice
title_sort chronic restraint stress inhibits hair growth via substance p mediated by reactive oxygen species in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637209/
https://www.ncbi.nlm.nih.gov/pubmed/23637859
http://dx.doi.org/10.1371/journal.pone.0061574
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