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A Novel Anti-Tumor Inhibitor Identified by Virtual Screen with PLK1 Structure and Zebrafish Assay

Polo-like kinase 1 (PLK1), one of the key regulators of mitosis, is a target for cancer therapy due to its abnormally high activity in several tumors. Plk1 is highly conserved and shares a nearly identical 3-D structure between zebrafish and humans. The initial 10 mitoses of zebrafish embryonic clea...

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Detalles Bibliográficos
Autores principales:	Lu, Jing, Xin, Shengchang, Meng, Huan, Veldman, Matt, Schoenfeld, David, Che, Chao, Yan, Ruibin, Zhong, Hanbing, Li, Song, Lin, Shuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637257/ https://www.ncbi.nlm.nih.gov/pubmed/23658603 http://dx.doi.org/10.1371/journal.pone.0053317

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