MHC Multimer-Guided and Cell Culture-Independent Isolation of Functional T Cell Receptors from Single Cells Facilitates TCR Identification for Immunotherapy

Adoptive therapy using T cells redirected to target tumor- or infection-associated antigens is a promising strategy that has curative potential and broad applicability. In order to accelerate the screening process for suitable antigen-specific T cell receptors (TCRs), we developed a new approach cir...

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Detalles Bibliográficos
Autores principales: Dössinger, Georg, Bunse, Mario, Bet, Jeannette, Albrecht, Julia, Paszkiewicz, Paulina J., Weißbrich, Bianca, Schiedewitz, Isabell, Henkel, Lynette, Schiemann, Matthias, Neuenhahn, Michael, Uckert, Wolfgang, Busch, Dirk H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637308/
https://www.ncbi.nlm.nih.gov/pubmed/23637823
http://dx.doi.org/10.1371/journal.pone.0061384

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