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18-fluorodeoxyglucose positron emission tomography for tuberculosis diagnosis and management: a case series
BACKGROUND: F-fluorodeoxyglucose positron emission tomography (FDG-PET) is increasingly used to investigate for malignancy in the evaluation of pulmonary nodules, yet both active tuberculosis (TB) and malignancy have high uptake of FDG. Definitive diagnosis of TB can be further hindered in patients...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637578/ https://www.ncbi.nlm.nih.gov/pubmed/23514625 http://dx.doi.org/10.1186/1471-2466-13-14 |
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author | Heysell, Scott K Thomas, Tania A Sifri, Costi D Rehm, Patrice K Houpt, Eric R |
author_facet | Heysell, Scott K Thomas, Tania A Sifri, Costi D Rehm, Patrice K Houpt, Eric R |
author_sort | Heysell, Scott K |
collection | PubMed |
description | BACKGROUND: F-fluorodeoxyglucose positron emission tomography (FDG-PET) is increasingly used to investigate for malignancy in the evaluation of pulmonary nodules, yet both active tuberculosis (TB) and malignancy have high uptake of FDG. Definitive diagnosis of TB can be further hindered in patients without growth of the organism from sputum. CASE PRESENTATIONS: We describe a series of four representative cases of TB in varying disease state originally imaged by FDG-PET during evaluation for malignancy. Decisions regarding treatment for active TB in the presence of negative cultures and the evolving understanding of the spectrum of the TB disease state are discussed. CONCLUSIONS: FDG-PET may possess a role in the diagnosis of active TB infection in settings where conventional microbiological methods are unavaiable and holds particular promise for monitoring response to therapy in cases of unsettled treatment duration such as multidrug-resistant TB or in extrapulmonary TB. |
format | Online Article Text |
id | pubmed-3637578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36375782013-04-28 18-fluorodeoxyglucose positron emission tomography for tuberculosis diagnosis and management: a case series Heysell, Scott K Thomas, Tania A Sifri, Costi D Rehm, Patrice K Houpt, Eric R BMC Pulm Med Case Report BACKGROUND: F-fluorodeoxyglucose positron emission tomography (FDG-PET) is increasingly used to investigate for malignancy in the evaluation of pulmonary nodules, yet both active tuberculosis (TB) and malignancy have high uptake of FDG. Definitive diagnosis of TB can be further hindered in patients without growth of the organism from sputum. CASE PRESENTATIONS: We describe a series of four representative cases of TB in varying disease state originally imaged by FDG-PET during evaluation for malignancy. Decisions regarding treatment for active TB in the presence of negative cultures and the evolving understanding of the spectrum of the TB disease state are discussed. CONCLUSIONS: FDG-PET may possess a role in the diagnosis of active TB infection in settings where conventional microbiological methods are unavaiable and holds particular promise for monitoring response to therapy in cases of unsettled treatment duration such as multidrug-resistant TB or in extrapulmonary TB. BioMed Central 2013-03-21 /pmc/articles/PMC3637578/ /pubmed/23514625 http://dx.doi.org/10.1186/1471-2466-13-14 Text en Copyright © 2013 Heysell et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Heysell, Scott K Thomas, Tania A Sifri, Costi D Rehm, Patrice K Houpt, Eric R 18-fluorodeoxyglucose positron emission tomography for tuberculosis diagnosis and management: a case series |
title | 18-fluorodeoxyglucose positron emission tomography for tuberculosis diagnosis and management: a case series |
title_full | 18-fluorodeoxyglucose positron emission tomography for tuberculosis diagnosis and management: a case series |
title_fullStr | 18-fluorodeoxyglucose positron emission tomography for tuberculosis diagnosis and management: a case series |
title_full_unstemmed | 18-fluorodeoxyglucose positron emission tomography for tuberculosis diagnosis and management: a case series |
title_short | 18-fluorodeoxyglucose positron emission tomography for tuberculosis diagnosis and management: a case series |
title_sort | 18-fluorodeoxyglucose positron emission tomography for tuberculosis diagnosis and management: a case series |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637578/ https://www.ncbi.nlm.nih.gov/pubmed/23514625 http://dx.doi.org/10.1186/1471-2466-13-14 |
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