Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging

Biomimetic synthesis has become a promising green pathway to prepare nanomaterials. In this study, bovine serum albumin (BSA)-conjugated gold nanoclusters/nanoparticles were successfully synthesized in water at room temperature by a protein-directed, solution-phase, green synthetic method. The synth...

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Detalles Bibliográficos
Autores principales: Lin, Jing, Zhou, Zhijun, Li, Zhiming, Zhang, Chunlei, Wang, Xiansong, Wang, Kan, Gao, Guo, Huang, Peng, Cui, Daxiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2013
Materias:
Nano Express
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637621/
https://www.ncbi.nlm.nih.gov/pubmed/23587362
http://dx.doi.org/10.1186/1556-276X-8-170
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author Lin, Jing
Zhou, Zhijun
Li, Zhiming
Zhang, Chunlei
Wang, Xiansong
Wang, Kan
Gao, Guo
Huang, Peng
Cui, Daxiang
author_facet Lin, Jing
Zhou, Zhijun
Li, Zhiming
Zhang, Chunlei
Wang, Xiansong
Wang, Kan
Gao, Guo
Huang, Peng
Cui, Daxiang
author_sort Lin, Jing
collection PubMed
description Biomimetic synthesis has become a promising green pathway to prepare nanomaterials. In this study, bovine serum albumin (BSA)-conjugated gold nanoclusters/nanoparticles were successfully synthesized in water at room temperature by a protein-directed, solution-phase, green synthetic method. The synthesized BSA-Au nanocomplexes have fluorescence emission (588 nm) of gold nanoclusters and surface plasmon resonance of gold nanoparticles. The BSA-Au nanocomplexes display non-cytotoxicity and excellent biocompatibility on MGC803 gastric cancer cells. After conjugation of folic acid molecules, the obtained BSA-Au nanocomplexes showed highly selective targeting for MGC803 cells and dual-modality dark-field and fluorescence imaging.
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spelling pubmed-36376212013-05-01 Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging Lin, Jing Zhou, Zhijun Li, Zhiming Zhang, Chunlei Wang, Xiansong Wang, Kan Gao, Guo Huang, Peng Cui, Daxiang Nanoscale Res Lett Nano Express Biomimetic synthesis has become a promising green pathway to prepare nanomaterials. In this study, bovine serum albumin (BSA)-conjugated gold nanoclusters/nanoparticles were successfully synthesized in water at room temperature by a protein-directed, solution-phase, green synthetic method. The synthesized BSA-Au nanocomplexes have fluorescence emission (588 nm) of gold nanoclusters and surface plasmon resonance of gold nanoparticles. The BSA-Au nanocomplexes display non-cytotoxicity and excellent biocompatibility on MGC803 gastric cancer cells. After conjugation of folic acid molecules, the obtained BSA-Au nanocomplexes showed highly selective targeting for MGC803 cells and dual-modality dark-field and fluorescence imaging. Springer 2013-04-15 /pmc/articles/PMC3637621/ /pubmed/23587362 http://dx.doi.org/10.1186/1556-276X-8-170 Text en Copyright ©2013 Lin et al.; licensee Springer. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Nano Express
Lin, Jing
Zhou, Zhijun
Li, Zhiming
Zhang, Chunlei
Wang, Xiansong
Wang, Kan
Gao, Guo
Huang, Peng
Cui, Daxiang
Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging
title Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging
title_full Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging
title_fullStr Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging
title_full_unstemmed Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging
title_short Biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging
title_sort biomimetic one-pot synthesis of gold nanoclusters/nanoparticles for targeted tumor cellular dual-modality imaging
topic Nano Express
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637621/
https://www.ncbi.nlm.nih.gov/pubmed/23587362
http://dx.doi.org/10.1186/1556-276X-8-170
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