Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

Current HIV-1 vaccines elicit strain-specific neutralizing antibodies. However, cross-reactive neutralizing antibodies arise in ~20% of HIV-1-infected individuals, and details of their generation could provide a roadmap for effective vaccination. Here we report the isolation, evolution and structure...

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Detalles Bibliográficos
Autores principales: Liao, Hua-Xin, Lynch, Rebecca, Zhou, Tongqing, Gao, Feng, Alam, S. Munir, Boyd, Scott D., Fire, Andrew Z., Roskin, Krishna M., Schramm, Chaim A., Zhang, Zhenhai, Zhu, Jiang, Shapiro, Lawrence, Mullikin, James C., Gnanakaran, S., Hraber, Peter, Wiehe, Kevin, Kelsoe, Garnett, Yang, Guang, Xia, Shi-Mao, Montefiori, David C., Parks, Robert, Lloyd, Krissey E., Scearce, Richard M., Soderberg, Kelly A., Cohen, Myron, Kaminga, Gift, Louder, Mark K., Tran, Lillan M., Chen, Yue, Cai, Fangping, Chen, Sheri, Moquin, Stephanie, Du, Xiulian, Joyce, Gordon M., Srivatsan, Sanjay, Zhang, Baoshan, Zheng, Anqi, Shaw, George M., Hahn, Beatrice H., Kepler, Thomas B., Korber, Bette T.M., Kwong, Peter D., Mascola, John R., Haynes, Barton F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637846/
https://www.ncbi.nlm.nih.gov/pubmed/23552890
http://dx.doi.org/10.1038/nature12053

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