Cargando…

Saffron Aqueous Extract Inhibits the Chemically-induced Gastric Cancer Progression in the Wistar Albino Rat

Objective(s): Gastric cancer is the first and second leading cause of cancer related death in Iranian men and women, respectively. Gastric cancer management is based on the surgery, radiotherapy and chemotherapy. In the present study, for the first time, the beneficial effect of saffron (Crocus sati...

Descripción completa

Detalles Bibliográficos
Autores principales: Bathaie, S. Zahra, Miri, Hamidreza, Mohagheghi, Mohammad-Ali, Mokhtari- Dizaji, Manijeh, Shahbazfar, Amir-Ali, Hasanzadeh, Hadi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637902/
https://www.ncbi.nlm.nih.gov/pubmed/23638290
_version_ 1782475793022058496
author Bathaie, S. Zahra
Miri, Hamidreza
Mohagheghi, Mohammad-Ali
Mokhtari- Dizaji, Manijeh
Shahbazfar, Amir-Ali
Hasanzadeh, Hadi
author_facet Bathaie, S. Zahra
Miri, Hamidreza
Mohagheghi, Mohammad-Ali
Mokhtari- Dizaji, Manijeh
Shahbazfar, Amir-Ali
Hasanzadeh, Hadi
author_sort Bathaie, S. Zahra
collection PubMed
description Objective(s): Gastric cancer is the first and second leading cause of cancer related death in Iranian men and women, respectively. Gastric cancer management is based on the surgery, radiotherapy and chemotherapy. In the present study, for the first time, the beneficial effect of saffron (Crocus sativus L.) aqueous extract (SAE) on the 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG)-induced gastric cancer in rat was investigated. Materials and Methods: MNNG was used to induce gastric cancer and then, different concentrations of SAE were administered to rats. After sacrificing, the stomach tissue was investigated by both pathologist and flow cytometry, and several biochemical parameters was determined in the plasma (or serum) and stomach of rats. Results: Pathologic data indicated the induction of cancer at different stages from hyperplasia to adenoma in rats; and the inhibition of cancer progression in the gastric tissue by SAE administration; so that, 20% of cancerous rats treated with higher doses of SAE was completely normal at the end of experiment and there was no rat with adenoma in the SAE treated groups. In addition, the results of the flow cytometry/ propidium iodide staining showed that the apoptosis/proliferation ratio was increased due to the SAE treatment of cancerous rats. Moreover, the significantly increased serum LDH and decreased plasma antioxidant activity due to cancer induction fell backwards after treatment of rats with SAE. But changes in the other parameters (Ca(2+), tyrosine kinase activity and carcino-embryonic antigen) were not significant. Conclusion: SAE inhibits the progression of gastric cancer in rats, in a dose dependent manner.
format Online
Article
Text
id pubmed-3637902
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Mashhad University of Medical Sciences
record_format MEDLINE/PubMed
spelling pubmed-36379022013-05-01 Saffron Aqueous Extract Inhibits the Chemically-induced Gastric Cancer Progression in the Wistar Albino Rat Bathaie, S. Zahra Miri, Hamidreza Mohagheghi, Mohammad-Ali Mokhtari- Dizaji, Manijeh Shahbazfar, Amir-Ali Hasanzadeh, Hadi Iran J Basic Med Sci Original Article Objective(s): Gastric cancer is the first and second leading cause of cancer related death in Iranian men and women, respectively. Gastric cancer management is based on the surgery, radiotherapy and chemotherapy. In the present study, for the first time, the beneficial effect of saffron (Crocus sativus L.) aqueous extract (SAE) on the 1-Methyl-3-nitro-1-nitrosoguanidine (MNNG)-induced gastric cancer in rat was investigated. Materials and Methods: MNNG was used to induce gastric cancer and then, different concentrations of SAE were administered to rats. After sacrificing, the stomach tissue was investigated by both pathologist and flow cytometry, and several biochemical parameters was determined in the plasma (or serum) and stomach of rats. Results: Pathologic data indicated the induction of cancer at different stages from hyperplasia to adenoma in rats; and the inhibition of cancer progression in the gastric tissue by SAE administration; so that, 20% of cancerous rats treated with higher doses of SAE was completely normal at the end of experiment and there was no rat with adenoma in the SAE treated groups. In addition, the results of the flow cytometry/ propidium iodide staining showed that the apoptosis/proliferation ratio was increased due to the SAE treatment of cancerous rats. Moreover, the significantly increased serum LDH and decreased plasma antioxidant activity due to cancer induction fell backwards after treatment of rats with SAE. But changes in the other parameters (Ca(2+), tyrosine kinase activity and carcino-embryonic antigen) were not significant. Conclusion: SAE inhibits the progression of gastric cancer in rats, in a dose dependent manner. Mashhad University of Medical Sciences 2013-01 /pmc/articles/PMC3637902/ /pubmed/23638290 Text en © 2013: Iranian Journal of Basic Medical Sciences This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bathaie, S. Zahra
Miri, Hamidreza
Mohagheghi, Mohammad-Ali
Mokhtari- Dizaji, Manijeh
Shahbazfar, Amir-Ali
Hasanzadeh, Hadi
Saffron Aqueous Extract Inhibits the Chemically-induced Gastric Cancer Progression in the Wistar Albino Rat
title Saffron Aqueous Extract Inhibits the Chemically-induced Gastric Cancer Progression in the Wistar Albino Rat
title_full Saffron Aqueous Extract Inhibits the Chemically-induced Gastric Cancer Progression in the Wistar Albino Rat
title_fullStr Saffron Aqueous Extract Inhibits the Chemically-induced Gastric Cancer Progression in the Wistar Albino Rat
title_full_unstemmed Saffron Aqueous Extract Inhibits the Chemically-induced Gastric Cancer Progression in the Wistar Albino Rat
title_short Saffron Aqueous Extract Inhibits the Chemically-induced Gastric Cancer Progression in the Wistar Albino Rat
title_sort saffron aqueous extract inhibits the chemically-induced gastric cancer progression in the wistar albino rat
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637902/
https://www.ncbi.nlm.nih.gov/pubmed/23638290
work_keys_str_mv AT bathaieszahra saffronaqueousextractinhibitsthechemicallyinducedgastriccancerprogressioninthewistaralbinorat
AT mirihamidreza saffronaqueousextractinhibitsthechemicallyinducedgastriccancerprogressioninthewistaralbinorat
AT mohagheghimohammadali saffronaqueousextractinhibitsthechemicallyinducedgastriccancerprogressioninthewistaralbinorat
AT mokhtaridizajimanijeh saffronaqueousextractinhibitsthechemicallyinducedgastriccancerprogressioninthewistaralbinorat
AT shahbazfaramirali saffronaqueousextractinhibitsthechemicallyinducedgastriccancerprogressioninthewistaralbinorat
AT hasanzadehhadi saffronaqueousextractinhibitsthechemicallyinducedgastriccancerprogressioninthewistaralbinorat