Effects of High Performance Inulin Supplementation on Glycemic Control and Antioxidant Status in Women with Type 2 Diabetes

BACKGROUND: The purpose of this study was to evaluate the effects of high performance inulin supplementation on blood glycemic control and antioxidant status in women with type 2 diabetes. METHODS: In a randomized, triple-blind controlled trial, 49 females (fiber intake <30 g/day, 25<body mass...

Descripción completa

Detalles Bibliográficos
Autores principales: Pourghassem Gargari, Bahram, Dehghan, Parvin, Aliasgharzadeh, Akbar, Asghari Jafar-abadi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638225/
https://www.ncbi.nlm.nih.gov/pubmed/23641355
http://dx.doi.org/10.4093/dmj.2013.37.2.140
_version_ 1782475807668568064
author Pourghassem Gargari, Bahram
Dehghan, Parvin
Aliasgharzadeh, Akbar
Asghari Jafar-abadi, Mohammad
author_facet Pourghassem Gargari, Bahram
Dehghan, Parvin
Aliasgharzadeh, Akbar
Asghari Jafar-abadi, Mohammad
author_sort Pourghassem Gargari, Bahram
collection PubMed
description BACKGROUND: The purpose of this study was to evaluate the effects of high performance inulin supplementation on blood glycemic control and antioxidant status in women with type 2 diabetes. METHODS: In a randomized, triple-blind controlled trial, 49 females (fiber intake <30 g/day, 25<body mass index <35 kg/m(2)) with type 2 diabetes were recruited from the Iran Diabetes Society and from endocrinology and metabolism clinics associated with the Tabriz University of Medical Science. The participants were divided into one of two groups in which the participants either received 10 g/day of inulin (intervention, n=24) or maltodextrin (control, n=25) for 2 months. Fasting blood samples were obtained and both glycemic control and antioxidant status were determined at baseline and at the end of the study. RESULTS: At the end of the study period, there were significant decreases in fasting plasma glucose (8.47%), glycosylated hemoglobin (10.43%), and malondialdehyde (37.21%) levels and significant increases in total antioxidant capacity (18.82%) and superoxide dismutase activity (4.36%) in the inulin group when compared to the maltodextrin group (P<0.05). Changes in fasting insulin, homeostasis model assessment of insulin resistance, and catalase activity were not significant in the inulin group when compared with the maltodextrin group. Glutathione peroxidase activity remained unchanged in both groups. CONCLUSION: Inulin supplementation may improve some glycemic and antioxidant indices and decrease malondialdehyde levels in women with type 2 diabetes. Further investigations are needed in order to confirm the positive effects that inulin may have on the glycemic and antioxidant indices of patients with type 2 diabetes.
format Online
Article
Text
id pubmed-3638225
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Korean Diabetes Association
record_format MEDLINE/PubMed
spelling pubmed-36382252013-05-02 Effects of High Performance Inulin Supplementation on Glycemic Control and Antioxidant Status in Women with Type 2 Diabetes Pourghassem Gargari, Bahram Dehghan, Parvin Aliasgharzadeh, Akbar Asghari Jafar-abadi, Mohammad Diabetes Metab J Original Article BACKGROUND: The purpose of this study was to evaluate the effects of high performance inulin supplementation on blood glycemic control and antioxidant status in women with type 2 diabetes. METHODS: In a randomized, triple-blind controlled trial, 49 females (fiber intake <30 g/day, 25<body mass index <35 kg/m(2)) with type 2 diabetes were recruited from the Iran Diabetes Society and from endocrinology and metabolism clinics associated with the Tabriz University of Medical Science. The participants were divided into one of two groups in which the participants either received 10 g/day of inulin (intervention, n=24) or maltodextrin (control, n=25) for 2 months. Fasting blood samples were obtained and both glycemic control and antioxidant status were determined at baseline and at the end of the study. RESULTS: At the end of the study period, there were significant decreases in fasting plasma glucose (8.47%), glycosylated hemoglobin (10.43%), and malondialdehyde (37.21%) levels and significant increases in total antioxidant capacity (18.82%) and superoxide dismutase activity (4.36%) in the inulin group when compared to the maltodextrin group (P<0.05). Changes in fasting insulin, homeostasis model assessment of insulin resistance, and catalase activity were not significant in the inulin group when compared with the maltodextrin group. Glutathione peroxidase activity remained unchanged in both groups. CONCLUSION: Inulin supplementation may improve some glycemic and antioxidant indices and decrease malondialdehyde levels in women with type 2 diabetes. Further investigations are needed in order to confirm the positive effects that inulin may have on the glycemic and antioxidant indices of patients with type 2 diabetes. Korean Diabetes Association 2013-04 2013-04-16 /pmc/articles/PMC3638225/ /pubmed/23641355 http://dx.doi.org/10.4093/dmj.2013.37.2.140 Text en Copyright © 2013 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Pourghassem Gargari, Bahram
Dehghan, Parvin
Aliasgharzadeh, Akbar
Asghari Jafar-abadi, Mohammad
Effects of High Performance Inulin Supplementation on Glycemic Control and Antioxidant Status in Women with Type 2 Diabetes
title Effects of High Performance Inulin Supplementation on Glycemic Control and Antioxidant Status in Women with Type 2 Diabetes
title_full Effects of High Performance Inulin Supplementation on Glycemic Control and Antioxidant Status in Women with Type 2 Diabetes
title_fullStr Effects of High Performance Inulin Supplementation on Glycemic Control and Antioxidant Status in Women with Type 2 Diabetes
title_full_unstemmed Effects of High Performance Inulin Supplementation on Glycemic Control and Antioxidant Status in Women with Type 2 Diabetes
title_short Effects of High Performance Inulin Supplementation on Glycemic Control and Antioxidant Status in Women with Type 2 Diabetes
title_sort effects of high performance inulin supplementation on glycemic control and antioxidant status in women with type 2 diabetes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638225/
https://www.ncbi.nlm.nih.gov/pubmed/23641355
http://dx.doi.org/10.4093/dmj.2013.37.2.140
work_keys_str_mv AT pourghassemgargaribahram effectsofhighperformanceinulinsupplementationonglycemiccontrolandantioxidantstatusinwomenwithtype2diabetes
AT dehghanparvin effectsofhighperformanceinulinsupplementationonglycemiccontrolandantioxidantstatusinwomenwithtype2diabetes
AT aliasgharzadehakbar effectsofhighperformanceinulinsupplementationonglycemiccontrolandantioxidantstatusinwomenwithtype2diabetes
AT asgharijafarabadimohammad effectsofhighperformanceinulinsupplementationonglycemiccontrolandantioxidantstatusinwomenwithtype2diabetes

Ejemplares similares