Genomic Profiling Reveals the Potential Role of TCL1A and MDR1 Deficiency in Chemotherapy-Induced Cardiotoxicity

Background: Anthracyclines, such as doxorubicin (Adriamycin), are highly effective chemotherapeutic agents, but are well known to cause myocardial dysfunction and life-threatening congestive heart failure (CHF) in some patients. Methods: To generate new hypotheses about its etiology, genome-wide tra...

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Detalles Bibliográficos
Autores principales: McCaffrey, Timothy A., Tziros, Constantine, Lewis, Jannet, Katz, Richard, Siegel, Robert, Weglicki, William, Kramer, Jay, Mak, I. Tong, Toma, Ian, Chen, Liang, Benas, Elizabeth, Lowitt, Alexander, Rao, Shruti, Witkin, Linda, Lian, Yi, Lai, Yinglei, Yang, Zhaoqing, Fu, Sidney W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638290/
https://www.ncbi.nlm.nih.gov/pubmed/23630447
http://dx.doi.org/10.7150/ijbs.6058

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