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Case treated with triple therapy of lamivudine, interferon-β and prednisolone for acute exacerbation of chronic hepatitis B during pregnancy

We herein report a case of a pregnant Chinese woman who suffered an acute exacerbation of hepatitis B. The patient's liver enzymes became elevated toward the end of the first trimester. She was treated with lamivudine, interferon (IFN)-β and steroids early in the second trimester. After this tr...

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Autores principales: Koh, Maki, Shinohara, Jun, Hongo, Yasushi, Okazaki, Tadashi, Takitani, Kimitaka, Tamai, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Asia 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638365/
https://www.ncbi.nlm.nih.gov/pubmed/23560863
http://dx.doi.org/10.1111/j.1872-034X.2012.01077.x
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author Koh, Maki
Shinohara, Jun
Hongo, Yasushi
Okazaki, Tadashi
Takitani, Kimitaka
Tamai, Hiroshi
author_facet Koh, Maki
Shinohara, Jun
Hongo, Yasushi
Okazaki, Tadashi
Takitani, Kimitaka
Tamai, Hiroshi
author_sort Koh, Maki
collection PubMed
description We herein report a case of a pregnant Chinese woman who suffered an acute exacerbation of hepatitis B. The patient's liver enzymes became elevated toward the end of the first trimester. She was treated with lamivudine, interferon (IFN)-β and steroids early in the second trimester. After this treatment regimen was initiated, aminotransferase levels rapidly normalized within 4 weeks. IFN-β and steroids were administrated for 2 weeks in the second trimester, while the administration of lamivudine continued until delivery. The spontaneous delivery of a female baby weighing 2984 g occurred at 37 weeks of gestation. A neonatal examination revealed no congenital anomalies, and fetal growth was found to be within normal reference ranges. The infant received simultaneous active and passive hepatitis B virus immunization within 12 h of delivery and completed the hepatitis B vaccine schedule at 2, 3 and 5 months of age. The infant was successfully prevented from contracting hepatitis B virus. This case suggests that combination therapy with lamivudine, IFN-β and steroids may be safely used during the second trimester to treat acute exacerbations of hepatitis B.
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spelling pubmed-36383652013-04-29 Case treated with triple therapy of lamivudine, interferon-β and prednisolone for acute exacerbation of chronic hepatitis B during pregnancy Koh, Maki Shinohara, Jun Hongo, Yasushi Okazaki, Tadashi Takitani, Kimitaka Tamai, Hiroshi Hepatol Res Case Reports We herein report a case of a pregnant Chinese woman who suffered an acute exacerbation of hepatitis B. The patient's liver enzymes became elevated toward the end of the first trimester. She was treated with lamivudine, interferon (IFN)-β and steroids early in the second trimester. After this treatment regimen was initiated, aminotransferase levels rapidly normalized within 4 weeks. IFN-β and steroids were administrated for 2 weeks in the second trimester, while the administration of lamivudine continued until delivery. The spontaneous delivery of a female baby weighing 2984 g occurred at 37 weeks of gestation. A neonatal examination revealed no congenital anomalies, and fetal growth was found to be within normal reference ranges. The infant received simultaneous active and passive hepatitis B virus immunization within 12 h of delivery and completed the hepatitis B vaccine schedule at 2, 3 and 5 months of age. The infant was successfully prevented from contracting hepatitis B virus. This case suggests that combination therapy with lamivudine, IFN-β and steroids may be safely used during the second trimester to treat acute exacerbations of hepatitis B. Blackwell Publishing Asia 2013-04 /pmc/articles/PMC3638365/ /pubmed/23560863 http://dx.doi.org/10.1111/j.1872-034X.2012.01077.x Text en Copyright © 2013 The Japan Society of Hepatology http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Case Reports
Koh, Maki
Shinohara, Jun
Hongo, Yasushi
Okazaki, Tadashi
Takitani, Kimitaka
Tamai, Hiroshi
Case treated with triple therapy of lamivudine, interferon-β and prednisolone for acute exacerbation of chronic hepatitis B during pregnancy
title Case treated with triple therapy of lamivudine, interferon-β and prednisolone for acute exacerbation of chronic hepatitis B during pregnancy
title_full Case treated with triple therapy of lamivudine, interferon-β and prednisolone for acute exacerbation of chronic hepatitis B during pregnancy
title_fullStr Case treated with triple therapy of lamivudine, interferon-β and prednisolone for acute exacerbation of chronic hepatitis B during pregnancy
title_full_unstemmed Case treated with triple therapy of lamivudine, interferon-β and prednisolone for acute exacerbation of chronic hepatitis B during pregnancy
title_short Case treated with triple therapy of lamivudine, interferon-β and prednisolone for acute exacerbation of chronic hepatitis B during pregnancy
title_sort case treated with triple therapy of lamivudine, interferon-β and prednisolone for acute exacerbation of chronic hepatitis b during pregnancy
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638365/
https://www.ncbi.nlm.nih.gov/pubmed/23560863
http://dx.doi.org/10.1111/j.1872-034X.2012.01077.x
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