BRAF V600E-Negative Hairy Cell Leukaemia

Since the initial report of the BRAF V600E mutation in hairy cell leukemia, numerous investigators have demonstrated the presence of this activating mutation in nearly all cases of this disease. A case of hairy cell leukemia is documented with a classical clinical, morphological, immunophenotypic, a...

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Detalles Bibliográficos
Autores principales: Langabeer, Stephen E., O'Brien, David, McElligott, Anthony M., Lavin, Michelle, Browne, Paul V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638549/
https://www.ncbi.nlm.nih.gov/pubmed/23653869
http://dx.doi.org/10.1155/2013/513049
Descripción
Sumario:Since the initial report of the BRAF V600E mutation in hairy cell leukemia, numerous investigators have demonstrated the presence of this activating mutation in nearly all cases of this disease. A case of hairy cell leukemia is documented with a classical clinical, morphological, immunophenotypic, and cytochemical profile in which the BRAF V600E was not detected. The diagnostic and therapeutic implications are discussed.

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