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Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway
Ganoderma, also known as Lingzhi or Reishi, has been used for medicinal purposes in Asian countries for centuries. It is a medicinal fungus with a variety of biological properties including immunomodulatory and antitumor activities. In this study, we investigated the molecular mechanisms by which Ga...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638576/ https://www.ncbi.nlm.nih.gov/pubmed/23662119 http://dx.doi.org/10.1155/2013/219472 |
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author | Kuo, Han-Peng Hsu, Shih-Chung Ou, Chien-Chih Li, Jhy-Wei Tseng, Hsiu-Hsueh Chuang, Tzu-Chao Liu, Jah-Yao Chen, Shih-Jung Su, Muh-Hwan Cheng, Yung-Chi Chou, Wei-Yuan Kao, Ming-Ching |
author_facet | Kuo, Han-Peng Hsu, Shih-Chung Ou, Chien-Chih Li, Jhy-Wei Tseng, Hsiu-Hsueh Chuang, Tzu-Chao Liu, Jah-Yao Chen, Shih-Jung Su, Muh-Hwan Cheng, Yung-Chi Chou, Wei-Yuan Kao, Ming-Ching |
author_sort | Kuo, Han-Peng |
collection | PubMed |
description | Ganoderma, also known as Lingzhi or Reishi, has been used for medicinal purposes in Asian countries for centuries. It is a medicinal fungus with a variety of biological properties including immunomodulatory and antitumor activities. In this study, we investigated the molecular mechanisms by which Ganoderma tsugae (GT), one of the most common species of Ganoderma, inhibits the proliferation of HER2-overexpressing cancer cells. Here, we show that a quality assured extract of GT (GTE) inhibited the growth of HER2-overexpressing cancer cells in vitro and in vivo and enhanced the growth-inhibitory effect of antitumor drugs (e.g., taxol and cisplatin) in these cells. We also demonstrate that GTE induced cell cycle arrest by interfering with the HER2/PI3K/Akt signaling pathway. Furthermore, GTE curtailed the expression of the HER2 protein by modulating the transcriptional activity of the HER2 gene and the stability/degradation of the HER2 protein. In conclusion, this study suggests that GTE may be a useful adjuvant therapeutic agent in the treatment of cancer cells that highly express HER2. |
format | Online Article Text |
id | pubmed-3638576 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36385762013-05-09 Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway Kuo, Han-Peng Hsu, Shih-Chung Ou, Chien-Chih Li, Jhy-Wei Tseng, Hsiu-Hsueh Chuang, Tzu-Chao Liu, Jah-Yao Chen, Shih-Jung Su, Muh-Hwan Cheng, Yung-Chi Chou, Wei-Yuan Kao, Ming-Ching Evid Based Complement Alternat Med Research Article Ganoderma, also known as Lingzhi or Reishi, has been used for medicinal purposes in Asian countries for centuries. It is a medicinal fungus with a variety of biological properties including immunomodulatory and antitumor activities. In this study, we investigated the molecular mechanisms by which Ganoderma tsugae (GT), one of the most common species of Ganoderma, inhibits the proliferation of HER2-overexpressing cancer cells. Here, we show that a quality assured extract of GT (GTE) inhibited the growth of HER2-overexpressing cancer cells in vitro and in vivo and enhanced the growth-inhibitory effect of antitumor drugs (e.g., taxol and cisplatin) in these cells. We also demonstrate that GTE induced cell cycle arrest by interfering with the HER2/PI3K/Akt signaling pathway. Furthermore, GTE curtailed the expression of the HER2 protein by modulating the transcriptional activity of the HER2 gene and the stability/degradation of the HER2 protein. In conclusion, this study suggests that GTE may be a useful adjuvant therapeutic agent in the treatment of cancer cells that highly express HER2. Hindawi Publishing Corporation 2013 2013-04-07 /pmc/articles/PMC3638576/ /pubmed/23662119 http://dx.doi.org/10.1155/2013/219472 Text en Copyright © 2013 Han-Peng Kuo et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kuo, Han-Peng Hsu, Shih-Chung Ou, Chien-Chih Li, Jhy-Wei Tseng, Hsiu-Hsueh Chuang, Tzu-Chao Liu, Jah-Yao Chen, Shih-Jung Su, Muh-Hwan Cheng, Yung-Chi Chou, Wei-Yuan Kao, Ming-Ching Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway |
title |
Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway |
title_full |
Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway |
title_fullStr |
Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway |
title_full_unstemmed |
Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway |
title_short |
Ganoderma tsugae Extract Inhibits Growth of HER2-Overexpressing Cancer Cells via Modulation of HER2/PI3K/Akt Signaling Pathway |
title_sort | ganoderma tsugae extract inhibits growth of her2-overexpressing cancer cells via modulation of her2/pi3k/akt signaling pathway |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638576/ https://www.ncbi.nlm.nih.gov/pubmed/23662119 http://dx.doi.org/10.1155/2013/219472 |
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