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Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats
To examine gastrointestinal hormone profiles and functional changes in gastroesophageal reflux disease (GERD), blood levels of the orexigenic hormone ghrelin were measured in rats with experimentally induced GERD. During the experiment, plasma acyl ghrelin levels in GERD rats were higher than those...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638645/ https://www.ncbi.nlm.nih.gov/pubmed/23653638 http://dx.doi.org/10.1155/2013/504816 |
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author | Nahata, Miwa Saegusa, Yayoi Harada, Yumi Tsuchiya, Naoko Hattori, Tomohisa Takeda, Hiroshi |
author_facet | Nahata, Miwa Saegusa, Yayoi Harada, Yumi Tsuchiya, Naoko Hattori, Tomohisa Takeda, Hiroshi |
author_sort | Nahata, Miwa |
collection | PubMed |
description | To examine gastrointestinal hormone profiles and functional changes in gastroesophageal reflux disease (GERD), blood levels of the orexigenic hormone ghrelin were measured in rats with experimentally induced GERD. During the experiment, plasma acyl ghrelin levels in GERD rats were higher than those in sham-operated rats, although food intake was reduced in GERD rats. Although plasma levels of the appetite-suppressing hormone leptin were significantly decreased in GERD rats, no changes were observed in cholecystokinin levels. Repeated administration of rat ghrelin to GERD rats had no effect on the reduction in body weight or food intake. Therefore, these results suggest that aberrantly increased secretion of peripheral ghrelin and decreased ghrelin responsiveness may occur in GERD rats. Neuropeptide Y and agouti-related peptide mRNA expression in the hypothalamus of GERD rats was significantly increased, whereas proopiomelanocortin mRNA expression was significantly decreased compared to that in sham-operated rats. However, melanin-concentrating hormone (MCH) and prepro-orexin mRNA expression in the hypothalamus of GERD rats was similar to that in sham-operated rats. These results suggest that although GERD rats have higher plasma ghrelin levels, ghrelin signaling in GERD rats may be suppressed due to reduced MCH and/or orexin synthesis in the hypothalamus. |
format | Online Article Text |
id | pubmed-3638645 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36386452013-05-07 Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats Nahata, Miwa Saegusa, Yayoi Harada, Yumi Tsuchiya, Naoko Hattori, Tomohisa Takeda, Hiroshi Gastroenterol Res Pract Research Article To examine gastrointestinal hormone profiles and functional changes in gastroesophageal reflux disease (GERD), blood levels of the orexigenic hormone ghrelin were measured in rats with experimentally induced GERD. During the experiment, plasma acyl ghrelin levels in GERD rats were higher than those in sham-operated rats, although food intake was reduced in GERD rats. Although plasma levels of the appetite-suppressing hormone leptin were significantly decreased in GERD rats, no changes were observed in cholecystokinin levels. Repeated administration of rat ghrelin to GERD rats had no effect on the reduction in body weight or food intake. Therefore, these results suggest that aberrantly increased secretion of peripheral ghrelin and decreased ghrelin responsiveness may occur in GERD rats. Neuropeptide Y and agouti-related peptide mRNA expression in the hypothalamus of GERD rats was significantly increased, whereas proopiomelanocortin mRNA expression was significantly decreased compared to that in sham-operated rats. However, melanin-concentrating hormone (MCH) and prepro-orexin mRNA expression in the hypothalamus of GERD rats was similar to that in sham-operated rats. These results suggest that although GERD rats have higher plasma ghrelin levels, ghrelin signaling in GERD rats may be suppressed due to reduced MCH and/or orexin synthesis in the hypothalamus. Hindawi Publishing Corporation 2013 2013-04-04 /pmc/articles/PMC3638645/ /pubmed/23653638 http://dx.doi.org/10.1155/2013/504816 Text en Copyright © 2013 Miwa Nahata et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Nahata, Miwa Saegusa, Yayoi Harada, Yumi Tsuchiya, Naoko Hattori, Tomohisa Takeda, Hiroshi Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats |
title | Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats |
title_full | Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats |
title_fullStr | Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats |
title_full_unstemmed | Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats |
title_short | Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats |
title_sort | changes in ghrelin-related factors in gastroesophageal reflux disease in rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638645/ https://www.ncbi.nlm.nih.gov/pubmed/23653638 http://dx.doi.org/10.1155/2013/504816 |
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