Cargando…

Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats

To examine gastrointestinal hormone profiles and functional changes in gastroesophageal reflux disease (GERD), blood levels of the orexigenic hormone ghrelin were measured in rats with experimentally induced GERD. During the experiment, plasma acyl ghrelin levels in GERD rats were higher than those...

Descripción completa

Detalles Bibliográficos
Autores principales: Nahata, Miwa, Saegusa, Yayoi, Harada, Yumi, Tsuchiya, Naoko, Hattori, Tomohisa, Takeda, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638645/
https://www.ncbi.nlm.nih.gov/pubmed/23653638
http://dx.doi.org/10.1155/2013/504816
_version_ 1782475860161331200
author Nahata, Miwa
Saegusa, Yayoi
Harada, Yumi
Tsuchiya, Naoko
Hattori, Tomohisa
Takeda, Hiroshi
author_facet Nahata, Miwa
Saegusa, Yayoi
Harada, Yumi
Tsuchiya, Naoko
Hattori, Tomohisa
Takeda, Hiroshi
author_sort Nahata, Miwa
collection PubMed
description To examine gastrointestinal hormone profiles and functional changes in gastroesophageal reflux disease (GERD), blood levels of the orexigenic hormone ghrelin were measured in rats with experimentally induced GERD. During the experiment, plasma acyl ghrelin levels in GERD rats were higher than those in sham-operated rats, although food intake was reduced in GERD rats. Although plasma levels of the appetite-suppressing hormone leptin were significantly decreased in GERD rats, no changes were observed in cholecystokinin levels. Repeated administration of rat ghrelin to GERD rats had no effect on the reduction in body weight or food intake. Therefore, these results suggest that aberrantly increased secretion of peripheral ghrelin and decreased ghrelin responsiveness may occur in GERD rats. Neuropeptide Y and agouti-related peptide mRNA expression in the hypothalamus of GERD rats was significantly increased, whereas proopiomelanocortin mRNA expression was significantly decreased compared to that in sham-operated rats. However, melanin-concentrating hormone (MCH) and prepro-orexin mRNA expression in the hypothalamus of GERD rats was similar to that in sham-operated rats. These results suggest that although GERD rats have higher plasma ghrelin levels, ghrelin signaling in GERD rats may be suppressed due to reduced MCH and/or orexin synthesis in the hypothalamus.
format Online
Article
Text
id pubmed-3638645
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-36386452013-05-07 Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats Nahata, Miwa Saegusa, Yayoi Harada, Yumi Tsuchiya, Naoko Hattori, Tomohisa Takeda, Hiroshi Gastroenterol Res Pract Research Article To examine gastrointestinal hormone profiles and functional changes in gastroesophageal reflux disease (GERD), blood levels of the orexigenic hormone ghrelin were measured in rats with experimentally induced GERD. During the experiment, plasma acyl ghrelin levels in GERD rats were higher than those in sham-operated rats, although food intake was reduced in GERD rats. Although plasma levels of the appetite-suppressing hormone leptin were significantly decreased in GERD rats, no changes were observed in cholecystokinin levels. Repeated administration of rat ghrelin to GERD rats had no effect on the reduction in body weight or food intake. Therefore, these results suggest that aberrantly increased secretion of peripheral ghrelin and decreased ghrelin responsiveness may occur in GERD rats. Neuropeptide Y and agouti-related peptide mRNA expression in the hypothalamus of GERD rats was significantly increased, whereas proopiomelanocortin mRNA expression was significantly decreased compared to that in sham-operated rats. However, melanin-concentrating hormone (MCH) and prepro-orexin mRNA expression in the hypothalamus of GERD rats was similar to that in sham-operated rats. These results suggest that although GERD rats have higher plasma ghrelin levels, ghrelin signaling in GERD rats may be suppressed due to reduced MCH and/or orexin synthesis in the hypothalamus. Hindawi Publishing Corporation 2013 2013-04-04 /pmc/articles/PMC3638645/ /pubmed/23653638 http://dx.doi.org/10.1155/2013/504816 Text en Copyright © 2013 Miwa Nahata et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nahata, Miwa
Saegusa, Yayoi
Harada, Yumi
Tsuchiya, Naoko
Hattori, Tomohisa
Takeda, Hiroshi
Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats
title Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats
title_full Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats
title_fullStr Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats
title_full_unstemmed Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats
title_short Changes in Ghrelin-Related Factors in Gastroesophageal Reflux Disease in Rats
title_sort changes in ghrelin-related factors in gastroesophageal reflux disease in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638645/
https://www.ncbi.nlm.nih.gov/pubmed/23653638
http://dx.doi.org/10.1155/2013/504816
work_keys_str_mv AT nahatamiwa changesinghrelinrelatedfactorsingastroesophagealrefluxdiseaseinrats
AT saegusayayoi changesinghrelinrelatedfactorsingastroesophagealrefluxdiseaseinrats
AT haradayumi changesinghrelinrelatedfactorsingastroesophagealrefluxdiseaseinrats
AT tsuchiyanaoko changesinghrelinrelatedfactorsingastroesophagealrefluxdiseaseinrats
AT hattoritomohisa changesinghrelinrelatedfactorsingastroesophagealrefluxdiseaseinrats
AT takedahiroshi changesinghrelinrelatedfactorsingastroesophagealrefluxdiseaseinrats