Cargando…

Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors: Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes

Studies have demonstrated that total osteocalcin (TOC) is associated with metabolic syndrome (MetS) and therefore might influence the risk of cardiovascular disease in humans. Undercarboxylated osteocalcin (uOC) regulates insulin secretion and sensitivity in mice, but its relation to MetS in humans...

Descripción completa

Detalles Bibliográficos
Autores principales: Alfadda, Assim A., Masood, Afshan, Shaik, Shaffi Ahamed, Dekhil, Hafedh, Goran, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638647/
https://www.ncbi.nlm.nih.gov/pubmed/23653641
http://dx.doi.org/10.1155/2013/197519
_version_ 1782475860594393088
author Alfadda, Assim A.
Masood, Afshan
Shaik, Shaffi Ahamed
Dekhil, Hafedh
Goran, Michael
author_facet Alfadda, Assim A.
Masood, Afshan
Shaik, Shaffi Ahamed
Dekhil, Hafedh
Goran, Michael
author_sort Alfadda, Assim A.
collection PubMed
description Studies have demonstrated that total osteocalcin (TOC) is associated with metabolic syndrome (MetS) and therefore might influence the risk of cardiovascular disease in humans. Undercarboxylated osteocalcin (uOC) regulates insulin secretion and sensitivity in mice, but its relation to MetS in humans is unclear. We aimed to determine whether uOC is related to MetS and/or its individual components and other cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM), and whether TOC and uOC have utility in predicting the cardiovascular risk. We studied 203 T2DM patients with and without MetS. MetS was defined based on the NCEP-ATP III criteria. A correlation analysis was performed between the three outcome variables: (i) TOC, (ii) uOC, and (iii) carboxylated osteocalcin (cOC) and MetS components and other cardiovascular risk factors. Both TOC and uOC were significantly lower in patients with MetS compared to those without MetS, independent of body mass index. In patients with MetS, uOC was significantly and positively correlated with HDL cholesterol, while TOC was significantly and negatively correlated with serum triglycerides. We report for the first time that uOC is related to lipid indices in patients with T2DM. Further studies are necessary to determine whether uOC can be utilized for cardiovascular risk assessments in these patients.
format Online
Article
Text
id pubmed-3638647
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-36386472013-05-07 Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors: Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes Alfadda, Assim A. Masood, Afshan Shaik, Shaffi Ahamed Dekhil, Hafedh Goran, Michael Int J Endocrinol Clinical Study Studies have demonstrated that total osteocalcin (TOC) is associated with metabolic syndrome (MetS) and therefore might influence the risk of cardiovascular disease in humans. Undercarboxylated osteocalcin (uOC) regulates insulin secretion and sensitivity in mice, but its relation to MetS in humans is unclear. We aimed to determine whether uOC is related to MetS and/or its individual components and other cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM), and whether TOC and uOC have utility in predicting the cardiovascular risk. We studied 203 T2DM patients with and without MetS. MetS was defined based on the NCEP-ATP III criteria. A correlation analysis was performed between the three outcome variables: (i) TOC, (ii) uOC, and (iii) carboxylated osteocalcin (cOC) and MetS components and other cardiovascular risk factors. Both TOC and uOC were significantly lower in patients with MetS compared to those without MetS, independent of body mass index. In patients with MetS, uOC was significantly and positively correlated with HDL cholesterol, while TOC was significantly and negatively correlated with serum triglycerides. We report for the first time that uOC is related to lipid indices in patients with T2DM. Further studies are necessary to determine whether uOC can be utilized for cardiovascular risk assessments in these patients. Hindawi Publishing Corporation 2013 2013-04-09 /pmc/articles/PMC3638647/ /pubmed/23653641 http://dx.doi.org/10.1155/2013/197519 Text en Copyright © 2013 Assim A. Alfadda et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Alfadda, Assim A.
Masood, Afshan
Shaik, Shaffi Ahamed
Dekhil, Hafedh
Goran, Michael
Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors: Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes
title Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors: Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes
title_full Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors: Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes
title_fullStr Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors: Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes
title_full_unstemmed Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors: Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes
title_short Association between Osteocalcin, Metabolic Syndrome, and Cardiovascular Risk Factors: Role of Total and Undercarboxylated Osteocalcin in Patients with Type 2 Diabetes
title_sort association between osteocalcin, metabolic syndrome, and cardiovascular risk factors: role of total and undercarboxylated osteocalcin in patients with type 2 diabetes
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638647/
https://www.ncbi.nlm.nih.gov/pubmed/23653641
http://dx.doi.org/10.1155/2013/197519
work_keys_str_mv AT alfaddaassima associationbetweenosteocalcinmetabolicsyndromeandcardiovascularriskfactorsroleoftotalandundercarboxylatedosteocalcininpatientswithtype2diabetes
AT masoodafshan associationbetweenosteocalcinmetabolicsyndromeandcardiovascularriskfactorsroleoftotalandundercarboxylatedosteocalcininpatientswithtype2diabetes
AT shaikshaffiahamed associationbetweenosteocalcinmetabolicsyndromeandcardiovascularriskfactorsroleoftotalandundercarboxylatedosteocalcininpatientswithtype2diabetes
AT dekhilhafedh associationbetweenosteocalcinmetabolicsyndromeandcardiovascularriskfactorsroleoftotalandundercarboxylatedosteocalcininpatientswithtype2diabetes
AT goranmichael associationbetweenosteocalcinmetabolicsyndromeandcardiovascularriskfactorsroleoftotalandundercarboxylatedosteocalcininpatientswithtype2diabetes