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Current Aspects in the Pathophysiology and Treatment of Chronic Wounds in Diabetes Mellitus

Impaired wound healing is a frequent and very severe problem in patients with diabetes mellitus, yet little is known about the underlying pathomechanisms. In this paper we review the biology of wound healing with particular attention to the pathophysiology of chronic wounds in diabetic patients. The...

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Autores principales: Tsourdi, Elena, Barthel, Andreas, Rietzsch, Hannes, Reichel, Andreas, Bornstein, Stefan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638655/
https://www.ncbi.nlm.nih.gov/pubmed/23653894
http://dx.doi.org/10.1155/2013/385641
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author Tsourdi, Elena
Barthel, Andreas
Rietzsch, Hannes
Reichel, Andreas
Bornstein, Stefan R.
author_facet Tsourdi, Elena
Barthel, Andreas
Rietzsch, Hannes
Reichel, Andreas
Bornstein, Stefan R.
author_sort Tsourdi, Elena
collection PubMed
description Impaired wound healing is a frequent and very severe problem in patients with diabetes mellitus, yet little is known about the underlying pathomechanisms. In this paper we review the biology of wound healing with particular attention to the pathophysiology of chronic wounds in diabetic patients. The standard treatment of diabetic ulcers includes measures to optimize glycemic control as well as extensive debridement, infection elimination by antibiotic therapy based on wound pathogen cultures, the use of moisture dressings, and offloading high pressure from the wound bed. In this paper we discuss novel adjuvant therapies with particular reference to the use of autologous skin transplants for the treatment of diabetic foot ulcers which do not respond to standard care.
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spelling pubmed-36386552013-05-07 Current Aspects in the Pathophysiology and Treatment of Chronic Wounds in Diabetes Mellitus Tsourdi, Elena Barthel, Andreas Rietzsch, Hannes Reichel, Andreas Bornstein, Stefan R. Biomed Res Int Review Article Impaired wound healing is a frequent and very severe problem in patients with diabetes mellitus, yet little is known about the underlying pathomechanisms. In this paper we review the biology of wound healing with particular attention to the pathophysiology of chronic wounds in diabetic patients. The standard treatment of diabetic ulcers includes measures to optimize glycemic control as well as extensive debridement, infection elimination by antibiotic therapy based on wound pathogen cultures, the use of moisture dressings, and offloading high pressure from the wound bed. In this paper we discuss novel adjuvant therapies with particular reference to the use of autologous skin transplants for the treatment of diabetic foot ulcers which do not respond to standard care. Hindawi Publishing Corporation 2013 2013-04-07 /pmc/articles/PMC3638655/ /pubmed/23653894 http://dx.doi.org/10.1155/2013/385641 Text en Copyright © 2013 Elena Tsourdi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tsourdi, Elena
Barthel, Andreas
Rietzsch, Hannes
Reichel, Andreas
Bornstein, Stefan R.
Current Aspects in the Pathophysiology and Treatment of Chronic Wounds in Diabetes Mellitus
title Current Aspects in the Pathophysiology and Treatment of Chronic Wounds in Diabetes Mellitus
title_full Current Aspects in the Pathophysiology and Treatment of Chronic Wounds in Diabetes Mellitus
title_fullStr Current Aspects in the Pathophysiology and Treatment of Chronic Wounds in Diabetes Mellitus
title_full_unstemmed Current Aspects in the Pathophysiology and Treatment of Chronic Wounds in Diabetes Mellitus
title_short Current Aspects in the Pathophysiology and Treatment of Chronic Wounds in Diabetes Mellitus
title_sort current aspects in the pathophysiology and treatment of chronic wounds in diabetes mellitus
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638655/
https://www.ncbi.nlm.nih.gov/pubmed/23653894
http://dx.doi.org/10.1155/2013/385641
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