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Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C

Aim. Chronic hepatitis C (CHepC) is frequently associated with hepatic iron overload, yet mechanisms underlying iron-induced liver injury have not been elucidated. We examined the significance of iron deposition in hepatocytes (HC) and reticuloendothelial cells (REC) in CHepC. Methods. Stainable hep...

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Autores principales: Mitsuyoshi, Hironori, Yasui, Kohichiroh, Yamaguchi, Kanji, Minami, Masahito, Okanoue, Takeshi, Itoh, Yoshito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638689/
https://www.ncbi.nlm.nih.gov/pubmed/23653861
http://dx.doi.org/10.1155/2013/686420
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author Mitsuyoshi, Hironori
Yasui, Kohichiroh
Yamaguchi, Kanji
Minami, Masahito
Okanoue, Takeshi
Itoh, Yoshito
author_facet Mitsuyoshi, Hironori
Yasui, Kohichiroh
Yamaguchi, Kanji
Minami, Masahito
Okanoue, Takeshi
Itoh, Yoshito
author_sort Mitsuyoshi, Hironori
collection PubMed
description Aim. Chronic hepatitis C (CHepC) is frequently associated with hepatic iron overload, yet mechanisms underlying iron-induced liver injury have not been elucidated. We examined the significance of iron deposition in hepatocytes (HC) and reticuloendothelial cells (REC) in CHepC. Methods. Stainable hepatic iron was scored according to the iron deposition pattern in 373 patients. The levels of serum soluble TNF-α receptor (sTNFR2) and hepatic hepcidin mRNA and the efficacy of phlebotomy were compared among patients with different iron deposition patterns. Results. Serum transaminase levels and hepatic scores of stage, grade, and steatosis were higher in patients with REC iron staining than in those without. REC iron scores were independently associated with advanced stage. Serum sTNFR2 levels were significantly higher in patients with REC iron than in those without. REC iron scores were independently correlated with sTNFR2 levels. Compared with patients without stainable iron, those with iron overload had decreased ratios of hepcidin mRNA to serum ferritin. The efficacy of phlebotomy was greater in patients with REC iron than in those without REC iron. Conclusions. The present results show the importance of REC iron for the development of CHepC and the therapeutic effect of phlebotomy in CHepC.
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spelling pubmed-36386892013-05-07 Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C Mitsuyoshi, Hironori Yasui, Kohichiroh Yamaguchi, Kanji Minami, Masahito Okanoue, Takeshi Itoh, Yoshito Int J Hepatol Research Article Aim. Chronic hepatitis C (CHepC) is frequently associated with hepatic iron overload, yet mechanisms underlying iron-induced liver injury have not been elucidated. We examined the significance of iron deposition in hepatocytes (HC) and reticuloendothelial cells (REC) in CHepC. Methods. Stainable hepatic iron was scored according to the iron deposition pattern in 373 patients. The levels of serum soluble TNF-α receptor (sTNFR2) and hepatic hepcidin mRNA and the efficacy of phlebotomy were compared among patients with different iron deposition patterns. Results. Serum transaminase levels and hepatic scores of stage, grade, and steatosis were higher in patients with REC iron staining than in those without. REC iron scores were independently associated with advanced stage. Serum sTNFR2 levels were significantly higher in patients with REC iron than in those without. REC iron scores were independently correlated with sTNFR2 levels. Compared with patients without stainable iron, those with iron overload had decreased ratios of hepcidin mRNA to serum ferritin. The efficacy of phlebotomy was greater in patients with REC iron than in those without REC iron. Conclusions. The present results show the importance of REC iron for the development of CHepC and the therapeutic effect of phlebotomy in CHepC. Hindawi Publishing Corporation 2013 2013-04-04 /pmc/articles/PMC3638689/ /pubmed/23653861 http://dx.doi.org/10.1155/2013/686420 Text en Copyright © 2013 Hironori Mitsuyoshi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Mitsuyoshi, Hironori
Yasui, Kohichiroh
Yamaguchi, Kanji
Minami, Masahito
Okanoue, Takeshi
Itoh, Yoshito
Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C
title Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C
title_full Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C
title_fullStr Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C
title_full_unstemmed Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C
title_short Pathogenic Role of Iron Deposition in Reticuloendothelial Cells during the Development of Chronic Hepatitis C
title_sort pathogenic role of iron deposition in reticuloendothelial cells during the development of chronic hepatitis c
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3638689/
https://www.ncbi.nlm.nih.gov/pubmed/23653861
http://dx.doi.org/10.1155/2013/686420
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