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Extracellular vesicles: communication, coercion, and conditioning
Cells communicate with neighboring cells and condition their local environment by secreting soluble factors into the extracellular space. These well-studied facets of cell biology are essential for the establishment and maintenance of physiological homeostasis. However, accumulating evidence has rev...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639038/ https://www.ncbi.nlm.nih.gov/pubmed/23630232 http://dx.doi.org/10.1091/mbc.E12-08-0572 |
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author | Shifrin, David A. Beckler, Michelle Demory Coffey, Robert J. Tyska, Matthew J. |
author_facet | Shifrin, David A. Beckler, Michelle Demory Coffey, Robert J. Tyska, Matthew J. |
author_sort | Shifrin, David A. |
collection | PubMed |
description | Cells communicate with neighboring cells and condition their local environment by secreting soluble factors into the extracellular space. These well-studied facets of cell biology are essential for the establishment and maintenance of physiological homeostasis. However, accumulating evidence has revealed that specific ligands, enzymes, and macromolecules are distributed into the extracellular space by virtue of their association with small vesicles, which are released by a variety of cell types. Although the biological significance of such vesicles was initially debated, purification and subsequent functional studies have shown that these extracellular vesicles are bioactive organelles carrying a wide range of protein and nucleic acid cargoes. In many cases these vesicles are laden with molecules that are involved in cell signaling, although other diverse functions are being revealed at a rapid pace. In this Perspective, we discuss recent developments in the understanding of the major pathways of extracellular vesicle biogenesis and how these vesicles contribute to the maintenance of physiological homeostasis. |
format | Online Article Text |
id | pubmed-3639038 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The American Society for Cell Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-36390382013-07-16 Extracellular vesicles: communication, coercion, and conditioning Shifrin, David A. Beckler, Michelle Demory Coffey, Robert J. Tyska, Matthew J. Mol Biol Cell Perspective Cells communicate with neighboring cells and condition their local environment by secreting soluble factors into the extracellular space. These well-studied facets of cell biology are essential for the establishment and maintenance of physiological homeostasis. However, accumulating evidence has revealed that specific ligands, enzymes, and macromolecules are distributed into the extracellular space by virtue of their association with small vesicles, which are released by a variety of cell types. Although the biological significance of such vesicles was initially debated, purification and subsequent functional studies have shown that these extracellular vesicles are bioactive organelles carrying a wide range of protein and nucleic acid cargoes. In many cases these vesicles are laden with molecules that are involved in cell signaling, although other diverse functions are being revealed at a rapid pace. In this Perspective, we discuss recent developments in the understanding of the major pathways of extracellular vesicle biogenesis and how these vesicles contribute to the maintenance of physiological homeostasis. The American Society for Cell Biology 2013-05-01 /pmc/articles/PMC3639038/ /pubmed/23630232 http://dx.doi.org/10.1091/mbc.E12-08-0572 Text en © 2013 Shifrin et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell BD; are registered trademarks of The American Society of Cell Biology. |
spellingShingle | Perspective Shifrin, David A. Beckler, Michelle Demory Coffey, Robert J. Tyska, Matthew J. Extracellular vesicles: communication, coercion, and conditioning |
title | Extracellular vesicles: communication, coercion, and conditioning |
title_full | Extracellular vesicles: communication, coercion, and conditioning |
title_fullStr | Extracellular vesicles: communication, coercion, and conditioning |
title_full_unstemmed | Extracellular vesicles: communication, coercion, and conditioning |
title_short | Extracellular vesicles: communication, coercion, and conditioning |
title_sort | extracellular vesicles: communication, coercion, and conditioning |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639038/ https://www.ncbi.nlm.nih.gov/pubmed/23630232 http://dx.doi.org/10.1091/mbc.E12-08-0572 |
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