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Extracellular vesicles: communication, coercion, and conditioning

Cells communicate with neighboring cells and condition their local environment by secreting soluble factors into the extracellular space. These well-studied facets of cell biology are essential for the establishment and maintenance of physiological homeostasis. However, accumulating evidence has rev...

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Detalles Bibliográficos
Autores principales: Shifrin, David A., Beckler, Michelle Demory, Coffey, Robert J., Tyska, Matthew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639038/
https://www.ncbi.nlm.nih.gov/pubmed/23630232
http://dx.doi.org/10.1091/mbc.E12-08-0572
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author Shifrin, David A.
Beckler, Michelle Demory
Coffey, Robert J.
Tyska, Matthew J.
author_facet Shifrin, David A.
Beckler, Michelle Demory
Coffey, Robert J.
Tyska, Matthew J.
author_sort Shifrin, David A.
collection PubMed
description Cells communicate with neighboring cells and condition their local environment by secreting soluble factors into the extracellular space. These well-studied facets of cell biology are essential for the establishment and maintenance of physiological homeostasis. However, accumulating evidence has revealed that specific ligands, enzymes, and macromolecules are distributed into the extracellular space by virtue of their association with small vesicles, which are released by a variety of cell types. Although the biological significance of such vesicles was initially debated, purification and subsequent functional studies have shown that these extracellular vesicles are bioactive organelles carrying a wide range of protein and nucleic acid cargoes. In many cases these vesicles are laden with molecules that are involved in cell signaling, although other diverse functions are being revealed at a rapid pace. In this Perspective, we discuss recent developments in the understanding of the major pathways of extracellular vesicle biogenesis and how these vesicles contribute to the maintenance of physiological homeostasis.
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spelling pubmed-36390382013-07-16 Extracellular vesicles: communication, coercion, and conditioning Shifrin, David A. Beckler, Michelle Demory Coffey, Robert J. Tyska, Matthew J. Mol Biol Cell Perspective Cells communicate with neighboring cells and condition their local environment by secreting soluble factors into the extracellular space. These well-studied facets of cell biology are essential for the establishment and maintenance of physiological homeostasis. However, accumulating evidence has revealed that specific ligands, enzymes, and macromolecules are distributed into the extracellular space by virtue of their association with small vesicles, which are released by a variety of cell types. Although the biological significance of such vesicles was initially debated, purification and subsequent functional studies have shown that these extracellular vesicles are bioactive organelles carrying a wide range of protein and nucleic acid cargoes. In many cases these vesicles are laden with molecules that are involved in cell signaling, although other diverse functions are being revealed at a rapid pace. In this Perspective, we discuss recent developments in the understanding of the major pathways of extracellular vesicle biogenesis and how these vesicles contribute to the maintenance of physiological homeostasis. The American Society for Cell Biology 2013-05-01 /pmc/articles/PMC3639038/ /pubmed/23630232 http://dx.doi.org/10.1091/mbc.E12-08-0572 Text en © 2013 Shifrin et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0). “ASCB®,” “The American Society for Cell Biology®,” and “Molecular Biology of the Cell®” are registered trademarks of The American Society of Cell BD; are registered trademarks of The American Society of Cell Biology.
spellingShingle Perspective
Shifrin, David A.
Beckler, Michelle Demory
Coffey, Robert J.
Tyska, Matthew J.
Extracellular vesicles: communication, coercion, and conditioning
title Extracellular vesicles: communication, coercion, and conditioning
title_full Extracellular vesicles: communication, coercion, and conditioning
title_fullStr Extracellular vesicles: communication, coercion, and conditioning
title_full_unstemmed Extracellular vesicles: communication, coercion, and conditioning
title_short Extracellular vesicles: communication, coercion, and conditioning
title_sort extracellular vesicles: communication, coercion, and conditioning
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639038/
https://www.ncbi.nlm.nih.gov/pubmed/23630232
http://dx.doi.org/10.1091/mbc.E12-08-0572
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