A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization

Short, repetitive, G-rich telomeric sequences are synthesized by telomerase, a ribonucleoprotein consisting of telomerase reverse transcriptase (TERT) and an integrally associated RNA. Human TERT (hTERT) can repetitively reverse transcribe its RNA template, acting processively to add multiple telome...

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Detalles Bibliográficos
Autores principales: D'Souza, Yasmin, Chu, Tsz Wai, Autexier, Chantal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639057/
https://www.ncbi.nlm.nih.gov/pubmed/23447707
http://dx.doi.org/10.1091/mbc.E12-12-0889

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639057/
https://www.ncbi.nlm.nih.gov/pubmed/23447707
http://dx.doi.org/10.1091/mbc.E12-12-0889

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