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A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization
Short, repetitive, G-rich telomeric sequences are synthesized by telomerase, a ribonucleoprotein consisting of telomerase reverse transcriptase (TERT) and an integrally associated RNA. Human TERT (hTERT) can repetitively reverse transcribe its RNA template, acting processively to add multiple telome...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The American Society for Cell Biology
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639057/ https://www.ncbi.nlm.nih.gov/pubmed/23447707 http://dx.doi.org/10.1091/mbc.E12-12-0889 |