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High disease activity in ankylosing spondylitis is associated with increased serum sclerostin level and decreased wingless protein-3a signaling but is not linked with greater structural damage

BACKGROUND: Clinical activity of ankylosing spondylitis (AS) predicts the natural course of the disease and the response to treatment. Several molecules are involved in new bone formation resulting in structural damage in patients with AS. However, the link between the clinical and molecular phenome...

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Detalles Bibliográficos
Autores principales: Korkosz, Mariusz, Gąsowski, Jerzy, Leszczyński, Piotr, Pawlak-Buś, Katarzyna, Jeka, Sławomir, Kucharska, Ewa, Grodzicki, Tomasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639156/
https://www.ncbi.nlm.nih.gov/pubmed/23509994
http://dx.doi.org/10.1186/1471-2474-14-99