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“Self” versus “Non-Self” Connectivity Dictates Properties of Synaptic Transmission and Plasticity
Autapses are connections between a neuron and itself. These connections are morphologically similar to “normal” synapses between two different neurons, and thus were long thought to have similar properties of synaptic transmission. However, this has not been directly tested. Here, using a micro-isla...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639172/ https://www.ncbi.nlm.nih.gov/pubmed/23658626 http://dx.doi.org/10.1371/journal.pone.0062414 |
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author | Liu, Huisheng Chapman, Edwin R. Dean, Camin |
author_facet | Liu, Huisheng Chapman, Edwin R. Dean, Camin |
author_sort | Liu, Huisheng |
collection | PubMed |
description | Autapses are connections between a neuron and itself. These connections are morphologically similar to “normal” synapses between two different neurons, and thus were long thought to have similar properties of synaptic transmission. However, this has not been directly tested. Here, using a micro-island culture assay in which we can define the number of interconnected cells, we directly compared synaptic transmission in excitatory autapses and in two-neuron micronetworks consisting of two excitatory neurons, in which a neuron is connected to one other neuron and to itself. We discovered that autaptic synapses are optimized for maximal transmission, and exhibited enhanced EPSC amplitude, charge, and RRP size compared to interneuronal synapses. However, autapses are deficient in several aspects of synaptic plasticity. Short-term potentiation only became apparent when a neuron was connected to another neuron. This acquisition of plasticity only required reciprocal innervation with one other neuron; micronetworks consisting of just two interconnected neurons exhibited enhanced short-term plasticity in terms of paired pulse ratio (PPR) and release probability (Pr), compared to autapses. Interestingly, when a neuron was connected to another neuron, not only interneuronal synapses, but also the autaptic synapses on itself exhibited a trend toward enhanced short-term plasticity in terms of PPR and Pr. Thus neurons can distinguish whether they are connected via “self” or “non-self” synapses and have the ability to adjust their plasticity parameters when connected to other neurons. |
format | Online Article Text |
id | pubmed-3639172 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36391722013-05-08 “Self” versus “Non-Self” Connectivity Dictates Properties of Synaptic Transmission and Plasticity Liu, Huisheng Chapman, Edwin R. Dean, Camin PLoS One Research Article Autapses are connections between a neuron and itself. These connections are morphologically similar to “normal” synapses between two different neurons, and thus were long thought to have similar properties of synaptic transmission. However, this has not been directly tested. Here, using a micro-island culture assay in which we can define the number of interconnected cells, we directly compared synaptic transmission in excitatory autapses and in two-neuron micronetworks consisting of two excitatory neurons, in which a neuron is connected to one other neuron and to itself. We discovered that autaptic synapses are optimized for maximal transmission, and exhibited enhanced EPSC amplitude, charge, and RRP size compared to interneuronal synapses. However, autapses are deficient in several aspects of synaptic plasticity. Short-term potentiation only became apparent when a neuron was connected to another neuron. This acquisition of plasticity only required reciprocal innervation with one other neuron; micronetworks consisting of just two interconnected neurons exhibited enhanced short-term plasticity in terms of paired pulse ratio (PPR) and release probability (Pr), compared to autapses. Interestingly, when a neuron was connected to another neuron, not only interneuronal synapses, but also the autaptic synapses on itself exhibited a trend toward enhanced short-term plasticity in terms of PPR and Pr. Thus neurons can distinguish whether they are connected via “self” or “non-self” synapses and have the ability to adjust their plasticity parameters when connected to other neurons. Public Library of Science 2013-04-29 /pmc/articles/PMC3639172/ /pubmed/23658626 http://dx.doi.org/10.1371/journal.pone.0062414 Text en © 2013 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Liu, Huisheng Chapman, Edwin R. Dean, Camin “Self” versus “Non-Self” Connectivity Dictates Properties of Synaptic Transmission and Plasticity |
title | “Self” versus “Non-Self” Connectivity Dictates Properties of Synaptic Transmission and Plasticity |
title_full | “Self” versus “Non-Self” Connectivity Dictates Properties of Synaptic Transmission and Plasticity |
title_fullStr | “Self” versus “Non-Self” Connectivity Dictates Properties of Synaptic Transmission and Plasticity |
title_full_unstemmed | “Self” versus “Non-Self” Connectivity Dictates Properties of Synaptic Transmission and Plasticity |
title_short | “Self” versus “Non-Self” Connectivity Dictates Properties of Synaptic Transmission and Plasticity |
title_sort | “self” versus “non-self” connectivity dictates properties of synaptic transmission and plasticity |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639172/ https://www.ncbi.nlm.nih.gov/pubmed/23658626 http://dx.doi.org/10.1371/journal.pone.0062414 |
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