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Discovery of Trypanosomatid Parasites in Globally Distributed Drosophila Species
Microbial parasites of animals include bacteria, viruses, and various unicellular eukaryotes. Because of the difficulty in studying these microorganisms in both humans and disease vectors, laboratory models are commonly used for experimental analysis of host-parasite interactions. Drosophila is one...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639215/ https://www.ncbi.nlm.nih.gov/pubmed/23658617 http://dx.doi.org/10.1371/journal.pone.0061937 |
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author | Chandler, James Angus James, Pamela M. |
author_facet | Chandler, James Angus James, Pamela M. |
author_sort | Chandler, James Angus |
collection | PubMed |
description | Microbial parasites of animals include bacteria, viruses, and various unicellular eukaryotes. Because of the difficulty in studying these microorganisms in both humans and disease vectors, laboratory models are commonly used for experimental analysis of host-parasite interactions. Drosophila is one such model that has made significant contributions to our knowledge of bacterial, fungal, and viral infections. Despite this, less is known about other potential parasites associated with natural Drosophila populations. Here, we surveyed sixteen Drosophila populations comprising thirteen species from four continents and Hawaii and found that they are associated with an extensive diversity of trypanosomatids (Euglenozoa, Kinetoplastea). Phylogenetic analysis finds that Drosophila-associated trypanosomatids are closely related to taxa that are responsible for various types of leishmaniases and more distantly related to the taxa responsible for human African trypanosomiasis and Chagas disease. We suggest that Drosophila may provide a powerful system for studying the interactions between trypanosomatids and their hosts. |
format | Online Article Text |
id | pubmed-3639215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36392152013-05-08 Discovery of Trypanosomatid Parasites in Globally Distributed Drosophila Species Chandler, James Angus James, Pamela M. PLoS One Research Article Microbial parasites of animals include bacteria, viruses, and various unicellular eukaryotes. Because of the difficulty in studying these microorganisms in both humans and disease vectors, laboratory models are commonly used for experimental analysis of host-parasite interactions. Drosophila is one such model that has made significant contributions to our knowledge of bacterial, fungal, and viral infections. Despite this, less is known about other potential parasites associated with natural Drosophila populations. Here, we surveyed sixteen Drosophila populations comprising thirteen species from four continents and Hawaii and found that they are associated with an extensive diversity of trypanosomatids (Euglenozoa, Kinetoplastea). Phylogenetic analysis finds that Drosophila-associated trypanosomatids are closely related to taxa that are responsible for various types of leishmaniases and more distantly related to the taxa responsible for human African trypanosomiasis and Chagas disease. We suggest that Drosophila may provide a powerful system for studying the interactions between trypanosomatids and their hosts. Public Library of Science 2013-04-29 /pmc/articles/PMC3639215/ /pubmed/23658617 http://dx.doi.org/10.1371/journal.pone.0061937 Text en © 2013 Chandler, James http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Chandler, James Angus James, Pamela M. Discovery of Trypanosomatid Parasites in Globally Distributed Drosophila Species |
title | Discovery of Trypanosomatid Parasites in Globally Distributed Drosophila Species |
title_full | Discovery of Trypanosomatid Parasites in Globally Distributed Drosophila Species |
title_fullStr | Discovery of Trypanosomatid Parasites in Globally Distributed Drosophila Species |
title_full_unstemmed | Discovery of Trypanosomatid Parasites in Globally Distributed Drosophila Species |
title_short | Discovery of Trypanosomatid Parasites in Globally Distributed Drosophila Species |
title_sort | discovery of trypanosomatid parasites in globally distributed drosophila species |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639215/ https://www.ncbi.nlm.nih.gov/pubmed/23658617 http://dx.doi.org/10.1371/journal.pone.0061937 |
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