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Rotary ATPases: Models, machine elements and technical specifications

Rotary ATPases are molecular rotary motors involved in biological energy conversion. They either synthesize or hydrolyze the universal biological energy carrier adenosine triphosphate. Recent work has elucidated the general architecture and subunit compositions of all three sub-types of rotary ATPas...

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Detalles Bibliográficos
Autores principales: Stewart, Alastair G., Sobti, Meghna, Harvey, Richard P., Stock, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639240/
https://www.ncbi.nlm.nih.gov/pubmed/23369889
http://dx.doi.org/10.4161/bioa.23301
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author Stewart, Alastair G.
Sobti, Meghna
Harvey, Richard P.
Stock, Daniela
author_facet Stewart, Alastair G.
Sobti, Meghna
Harvey, Richard P.
Stock, Daniela
author_sort Stewart, Alastair G.
collection PubMed
description Rotary ATPases are molecular rotary motors involved in biological energy conversion. They either synthesize or hydrolyze the universal biological energy carrier adenosine triphosphate. Recent work has elucidated the general architecture and subunit compositions of all three sub-types of rotary ATPases. Composite models of the intact F-, V- and A-type ATPases have been constructed by fitting high-resolution X-ray structures of individual subunits or sub-complexes into low-resolution electron densities of the intact enzymes derived from electron cryo-microscopy. Electron cryo-tomography has provided new insights into the supra-molecular arrangement of eukaryotic ATP synthases within mitochondria and mass-spectrometry has started to identify specifically bound lipids presumed to be essential for function. Taken together these molecular snapshots show that nano-scale rotary engines have much in common with basic design principles of man made machines from the function of individual “machine elements” to the requirement of the right “fuel” and “oil” for different types of motors.
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spelling pubmed-36392402013-05-23 Rotary ATPases: Models, machine elements and technical specifications Stewart, Alastair G. Sobti, Meghna Harvey, Richard P. Stock, Daniela Bioarchitecture Review Rotary ATPases are molecular rotary motors involved in biological energy conversion. They either synthesize or hydrolyze the universal biological energy carrier adenosine triphosphate. Recent work has elucidated the general architecture and subunit compositions of all three sub-types of rotary ATPases. Composite models of the intact F-, V- and A-type ATPases have been constructed by fitting high-resolution X-ray structures of individual subunits or sub-complexes into low-resolution electron densities of the intact enzymes derived from electron cryo-microscopy. Electron cryo-tomography has provided new insights into the supra-molecular arrangement of eukaryotic ATP synthases within mitochondria and mass-spectrometry has started to identify specifically bound lipids presumed to be essential for function. Taken together these molecular snapshots show that nano-scale rotary engines have much in common with basic design principles of man made machines from the function of individual “machine elements” to the requirement of the right “fuel” and “oil” for different types of motors. Landes Bioscience 2013-01-01 2013-01-01 /pmc/articles/PMC3639240/ /pubmed/23369889 http://dx.doi.org/10.4161/bioa.23301 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Stewart, Alastair G.
Sobti, Meghna
Harvey, Richard P.
Stock, Daniela
Rotary ATPases: Models, machine elements and technical specifications
title Rotary ATPases: Models, machine elements and technical specifications
title_full Rotary ATPases: Models, machine elements and technical specifications
title_fullStr Rotary ATPases: Models, machine elements and technical specifications
title_full_unstemmed Rotary ATPases: Models, machine elements and technical specifications
title_short Rotary ATPases: Models, machine elements and technical specifications
title_sort rotary atpases: models, machine elements and technical specifications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639240/
https://www.ncbi.nlm.nih.gov/pubmed/23369889
http://dx.doi.org/10.4161/bioa.23301
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