An Ultra High-Throughput, Whole-Animal Screen for Small Molecule Modulators of a Specific Genetic Pathway in Caenorhabditis elegans

High-throughput screening (HTS) is a powerful approach to drug discovery, but many lead compounds are found to be unsuitable for use in vivo after initial screening. Screening in small animals like C. elegans can help avoid these problems, but this system has been limited to screens with low-through...

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Detalles Bibliográficos
Autores principales: Leung, Chi K., Wang, Ying, Malany, Siobhan, Deonarine, Andrew, Nguyen, Kevin, Vasile, Stefan, Choe, Keith P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639262/
https://www.ncbi.nlm.nih.gov/pubmed/23637990
http://dx.doi.org/10.1371/journal.pone.0062166

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639262/
https://www.ncbi.nlm.nih.gov/pubmed/23637990
http://dx.doi.org/10.1371/journal.pone.0062166

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