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Analysis of bone mineralization on uncemented femoral stems by [18F]-fluoride-PET: A randomized clinical study of 16 hips in 8 patients

PURPOSE: We present the first study using fluoride-positron emission CT (F-PET/CT) to analyze mineralization of bone in the femur adjacent to uncemented stems following total hip arthroplasty (THA). We studied patients who were operated bilaterally for osteoarthritis with 2 different stems during th...

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Autores principales: Ullmark, Gösta, Nilsson, Olle, Maripuu, Enn, Sörensen, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2013
Materias:
Hip
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639333/
https://www.ncbi.nlm.nih.gov/pubmed/23506163
http://dx.doi.org/10.3109/17453674.2013.786632
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author Ullmark, Gösta
Nilsson, Olle
Maripuu, Enn
Sörensen, Jens
author_facet Ullmark, Gösta
Nilsson, Olle
Maripuu, Enn
Sörensen, Jens
author_sort Ullmark, Gösta
collection PubMed
description PURPOSE: We present the first study using fluoride-positron emission CT (F-PET/CT) to analyze mineralization of bone in the femur adjacent to uncemented stems following total hip arthroplasty (THA). We studied patients who were operated bilaterally for osteoarthritis with 2 different stems during the same surgical session. PATIENTS AND METHODS: THA was performed bilaterally during the same surgical session in 8 patients with bilateral osteoarthritis of the hip. An SL-PLUS stem was inserted in one hip and a BetaCone stem was inserted in the contralateral hip, with randomization of side and sequence. A second group of 12 individuals with a normal healthy hip was used as reference for normal bone metabolism. Clinical and radiographic evaluation was performed preoperatively, postoperatively, and at 2 years. We used [18F]-fluoride-PET/CT to analyze bone mineralization adjacent to the stems 1 week, 4 months, and 12 months after surgery. We modified the Polar Map system to fit the upper femur for analysis and presentation of the PET results from 12 regions of interest adjacent to the whole stem. RESULTS: The clinical results were good at 2 years. By radiography, all stems were stable. At PET analyses 1 week after surgery, the activity was higher for the SL-PLUS group than for the BetaCone group. The activity was statistically significantly higher for both stems than the reference values at 4 months, and was most pronounced in the upper femur. At one year, the activity had declined more for the BC group than for the SL group. INTERPRETATION: The bone mineralization activity varied between different regions for the same stem and between different time periods for each group. F-PET/CT is a novel and valuable tool for analysis of bone mineralization patterns around uncemented femoral stems in detail. The combination of PET/CT analysis and the modified Polar Map system may provide a useful tool for future studies of metabolic bone responses to prosthetic implants.
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spelling pubmed-36393332013-05-02 Analysis of bone mineralization on uncemented femoral stems by [18F]-fluoride-PET: A randomized clinical study of 16 hips in 8 patients Ullmark, Gösta Nilsson, Olle Maripuu, Enn Sörensen, Jens Acta Orthop Hip PURPOSE: We present the first study using fluoride-positron emission CT (F-PET/CT) to analyze mineralization of bone in the femur adjacent to uncemented stems following total hip arthroplasty (THA). We studied patients who were operated bilaterally for osteoarthritis with 2 different stems during the same surgical session. PATIENTS AND METHODS: THA was performed bilaterally during the same surgical session in 8 patients with bilateral osteoarthritis of the hip. An SL-PLUS stem was inserted in one hip and a BetaCone stem was inserted in the contralateral hip, with randomization of side and sequence. A second group of 12 individuals with a normal healthy hip was used as reference for normal bone metabolism. Clinical and radiographic evaluation was performed preoperatively, postoperatively, and at 2 years. We used [18F]-fluoride-PET/CT to analyze bone mineralization adjacent to the stems 1 week, 4 months, and 12 months after surgery. We modified the Polar Map system to fit the upper femur for analysis and presentation of the PET results from 12 regions of interest adjacent to the whole stem. RESULTS: The clinical results were good at 2 years. By radiography, all stems were stable. At PET analyses 1 week after surgery, the activity was higher for the SL-PLUS group than for the BetaCone group. The activity was statistically significantly higher for both stems than the reference values at 4 months, and was most pronounced in the upper femur. At one year, the activity had declined more for the BC group than for the SL group. INTERPRETATION: The bone mineralization activity varied between different regions for the same stem and between different time periods for each group. F-PET/CT is a novel and valuable tool for analysis of bone mineralization patterns around uncemented femoral stems in detail. The combination of PET/CT analysis and the modified Polar Map system may provide a useful tool for future studies of metabolic bone responses to prosthetic implants. Informa Healthcare 2013-04 2013-04-18 /pmc/articles/PMC3639333/ /pubmed/23506163 http://dx.doi.org/10.3109/17453674.2013.786632 Text en Copyright: © Nordic Orthopaedic Federation http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited.
spellingShingle Hip
Ullmark, Gösta
Nilsson, Olle
Maripuu, Enn
Sörensen, Jens
Analysis of bone mineralization on uncemented femoral stems by [18F]-fluoride-PET: A randomized clinical study of 16 hips in 8 patients
title Analysis of bone mineralization on uncemented femoral stems by [18F]-fluoride-PET: A randomized clinical study of 16 hips in 8 patients
title_full Analysis of bone mineralization on uncemented femoral stems by [18F]-fluoride-PET: A randomized clinical study of 16 hips in 8 patients
title_fullStr Analysis of bone mineralization on uncemented femoral stems by [18F]-fluoride-PET: A randomized clinical study of 16 hips in 8 patients
title_full_unstemmed Analysis of bone mineralization on uncemented femoral stems by [18F]-fluoride-PET: A randomized clinical study of 16 hips in 8 patients
title_short Analysis of bone mineralization on uncemented femoral stems by [18F]-fluoride-PET: A randomized clinical study of 16 hips in 8 patients
title_sort analysis of bone mineralization on uncemented femoral stems by [18f]-fluoride-pet: a randomized clinical study of 16 hips in 8 patients
topic Hip
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639333/
https://www.ncbi.nlm.nih.gov/pubmed/23506163
http://dx.doi.org/10.3109/17453674.2013.786632
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