The level of origin firing inversely affects the rate of replication fork progression

DNA damage slows DNA synthesis at replication forks; however, the mechanisms remain unclear. Cdc7 kinase is required for replication origin activation, is a target of the intra-S checkpoint, and is implicated in the response to replication fork stress. Remarkably, we found that replication forks pro...

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Detalles Bibliográficos
Autores principales: Zhong, Yuan, Nellimoottil, Tittu, Peace, Jared M., Knott, Simon R.V., Villwock, Sandra K., Yee, Janis M., Jancuska, Jeffrey M., Rege, Sanket, Tecklenburg, Marianne, Sclafani, Robert A., Tavaré, Simon, Aparicio, Oscar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639389/
https://www.ncbi.nlm.nih.gov/pubmed/23629964
http://dx.doi.org/10.1083/jcb.201208060

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