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Quantitative properties and receptor reserve of the DAG and PKC branch of G(q)-coupled receptor signaling

G(q) protein–coupled receptors (G(q)PCRs) of the plasma membrane activate the phospholipase C (PLC) signaling cascade. PLC cleaves the membrane lipid phosphatidylinositol 4,5-bisphosphate (PIP(2)) into the second messengers diacylgycerol (DAG) and inositol 1,4,5-trisphosphate (IP(3)), leading to cal...

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Detalles Bibliográficos
Autores principales:	Falkenburger, Björn H., Dickson, Eamonn J., Hille, Bertil
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639584/ https://www.ncbi.nlm.nih.gov/pubmed/23630338 http://dx.doi.org/10.1085/jgp.201210887

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