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Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology
Plastic bronchitis (PB) is a pathologic condition in which airway casts develop in the tracheobronchial tree causing airway obstruction. There is no standard treatment strategy for this uncommon condition. We report an index patient treated using an emerging multimodal strategy of directly instilled...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639666/ https://www.ncbi.nlm.nih.gov/pubmed/23662235 http://dx.doi.org/10.1155/2013/649365 |
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author | Kunder, Rebecca Kunder, Christian Sun, Heather Y. Berry, Gerald Messner, Anna Frankovich, Jennifer Roth, Stephen Mark, John |
author_facet | Kunder, Rebecca Kunder, Christian Sun, Heather Y. Berry, Gerald Messner, Anna Frankovich, Jennifer Roth, Stephen Mark, John |
author_sort | Kunder, Rebecca |
collection | PubMed |
description | Plastic bronchitis (PB) is a pathologic condition in which airway casts develop in the tracheobronchial tree causing airway obstruction. There is no standard treatment strategy for this uncommon condition. We report an index patient treated using an emerging multimodal strategy of directly instilled and inhaled tissue plasminogen activator (t-PA) as well as 13 other cases of PB at our institution between 2000 and 2012. The majority of cases (n = 8) occurred in patients with congenital heart disease. Clinical presentations, treatments used, histopathology of the casts, and patient outcomes are reviewed. Further discussion is focused on the epidemiology of plastic bronchitis and a systematic approach to the histologic classification of casts. Comorbid conditions identified in this study included congenital heart disease (8), pneumonia (3), and asthma (2). Our institutional prevalence rate was 6.8 per 100,000 patients, and our case fatality rate was 7%. |
format | Online Article Text |
id | pubmed-3639666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36396662013-05-09 Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology Kunder, Rebecca Kunder, Christian Sun, Heather Y. Berry, Gerald Messner, Anna Frankovich, Jennifer Roth, Stephen Mark, John Case Rep Pulmonol Case Report Plastic bronchitis (PB) is a pathologic condition in which airway casts develop in the tracheobronchial tree causing airway obstruction. There is no standard treatment strategy for this uncommon condition. We report an index patient treated using an emerging multimodal strategy of directly instilled and inhaled tissue plasminogen activator (t-PA) as well as 13 other cases of PB at our institution between 2000 and 2012. The majority of cases (n = 8) occurred in patients with congenital heart disease. Clinical presentations, treatments used, histopathology of the casts, and patient outcomes are reviewed. Further discussion is focused on the epidemiology of plastic bronchitis and a systematic approach to the histologic classification of casts. Comorbid conditions identified in this study included congenital heart disease (8), pneumonia (3), and asthma (2). Our institutional prevalence rate was 6.8 per 100,000 patients, and our case fatality rate was 7%. Hindawi Publishing Corporation 2013 2013-04-11 /pmc/articles/PMC3639666/ /pubmed/23662235 http://dx.doi.org/10.1155/2013/649365 Text en Copyright © 2013 Rebecca Kunder et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Kunder, Rebecca Kunder, Christian Sun, Heather Y. Berry, Gerald Messner, Anna Frankovich, Jennifer Roth, Stephen Mark, John Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology |
title | Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology |
title_full | Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology |
title_fullStr | Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology |
title_full_unstemmed | Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology |
title_short | Pediatric Plastic Bronchitis: Case Report and Retrospective Comparative Analysis of Epidemiology and Pathology |
title_sort | pediatric plastic bronchitis: case report and retrospective comparative analysis of epidemiology and pathology |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639666/ https://www.ncbi.nlm.nih.gov/pubmed/23662235 http://dx.doi.org/10.1155/2013/649365 |
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