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Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma
BACKGROUND: Surgery remains the only curative option for the treatment of pancreatic adenocarcinoma (PDAC). The goal of this study was to investigate the clinical outcome and prognostic factors in patients after resection for ductal adenocarcinoma of the pancreatic head. METHODS: The data from 195 p...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639824/ https://www.ncbi.nlm.nih.gov/pubmed/23607915 http://dx.doi.org/10.1186/1471-2482-13-12 |
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author | Distler, Marius Rückert, Felix Hunger, Maximilian Kersting, Stephan Pilarsky, Christian Saeger, Hans-Detlev Grützmann, Robert |
author_facet | Distler, Marius Rückert, Felix Hunger, Maximilian Kersting, Stephan Pilarsky, Christian Saeger, Hans-Detlev Grützmann, Robert |
author_sort | Distler, Marius |
collection | PubMed |
description | BACKGROUND: Surgery remains the only curative option for the treatment of pancreatic adenocarcinoma (PDAC). The goal of this study was to investigate the clinical outcome and prognostic factors in patients after resection for ductal adenocarcinoma of the pancreatic head. METHODS: The data from 195 patients who underwent pancreatic head resection for PDAC between 1993 and 2011 in our center were retrospectively analyzed. The prognostic factors for survival after operation were evaluated using multivariate analysis. RESULTS: The head resection surgeries included 69.7% pylorus-preserving pancreatoduodenectomies (PPPD) and 30.3% standard Kausch-Whipple pancreatoduodenectomies (Whipple). The overall mortality after pancreatoduodenectomy (PD) was 4.1%, and the overall morbidity was 42%. The actuarial 3- and 5-year survival rates were 31.5% (95% CI, 25.04%-39.6%) and 11.86% (95% CI, 7.38%-19.0%), respectively. Univariate analyses demonstrated that elevated CEA (p = 0.002) and elevated CA 19–9 (p = 0.026) levels, tumor grade (p = 0.001) and hard texture of the pancreatic gland (p = 0.017) were significant predictors of a poor survival. However, only CEA >3 ng/ml (p < 0.005) and tumor grade 3 (p = 0.027) were validated as significant predictors of survival in multivariate analysis. CONCLUSIONS: Our results suggest that tumor marker levels and tumor grade are significant predictors of poor survival for patients with pancreatic head cancer. Furthermore, hard texture of the pancreatic gland appears to be associated with poor survival. |
format | Online Article Text |
id | pubmed-3639824 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36398242013-05-01 Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma Distler, Marius Rückert, Felix Hunger, Maximilian Kersting, Stephan Pilarsky, Christian Saeger, Hans-Detlev Grützmann, Robert BMC Surg Research Article BACKGROUND: Surgery remains the only curative option for the treatment of pancreatic adenocarcinoma (PDAC). The goal of this study was to investigate the clinical outcome and prognostic factors in patients after resection for ductal adenocarcinoma of the pancreatic head. METHODS: The data from 195 patients who underwent pancreatic head resection for PDAC between 1993 and 2011 in our center were retrospectively analyzed. The prognostic factors for survival after operation were evaluated using multivariate analysis. RESULTS: The head resection surgeries included 69.7% pylorus-preserving pancreatoduodenectomies (PPPD) and 30.3% standard Kausch-Whipple pancreatoduodenectomies (Whipple). The overall mortality after pancreatoduodenectomy (PD) was 4.1%, and the overall morbidity was 42%. The actuarial 3- and 5-year survival rates were 31.5% (95% CI, 25.04%-39.6%) and 11.86% (95% CI, 7.38%-19.0%), respectively. Univariate analyses demonstrated that elevated CEA (p = 0.002) and elevated CA 19–9 (p = 0.026) levels, tumor grade (p = 0.001) and hard texture of the pancreatic gland (p = 0.017) were significant predictors of a poor survival. However, only CEA >3 ng/ml (p < 0.005) and tumor grade 3 (p = 0.027) were validated as significant predictors of survival in multivariate analysis. CONCLUSIONS: Our results suggest that tumor marker levels and tumor grade are significant predictors of poor survival for patients with pancreatic head cancer. Furthermore, hard texture of the pancreatic gland appears to be associated with poor survival. BioMed Central 2013-04-22 /pmc/articles/PMC3639824/ /pubmed/23607915 http://dx.doi.org/10.1186/1471-2482-13-12 Text en Copyright © 2013 Distler et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Distler, Marius Rückert, Felix Hunger, Maximilian Kersting, Stephan Pilarsky, Christian Saeger, Hans-Detlev Grützmann, Robert Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma |
title | Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma |
title_full | Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma |
title_fullStr | Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma |
title_full_unstemmed | Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma |
title_short | Evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma |
title_sort | evaluation of survival in patients after pancreatic head resection for ductal adenocarcinoma |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639824/ https://www.ncbi.nlm.nih.gov/pubmed/23607915 http://dx.doi.org/10.1186/1471-2482-13-12 |
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