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Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models
Na(+)/K(+)-ATPase alpha 2 (Atp1a2) is an integral plasma membrane protein belonging to the P-type ATPase family that is responsible for maintaining the sodium (Na(+)) and potassium (K(+)) gradients across cellular membranes with hydrolysis of ATP. Atp1a2 contains two subunits, alpha and beta, with e...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639839/ https://www.ncbi.nlm.nih.gov/pubmed/23561701 http://dx.doi.org/10.1186/1479-7364-7-8 |
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author | Gritz, Stephanie M Radcliffe, Richard A |
author_facet | Gritz, Stephanie M Radcliffe, Richard A |
author_sort | Gritz, Stephanie M |
collection | PubMed |
description | Na(+)/K(+)-ATPase alpha 2 (Atp1a2) is an integral plasma membrane protein belonging to the P-type ATPase family that is responsible for maintaining the sodium (Na(+)) and potassium (K(+)) gradients across cellular membranes with hydrolysis of ATP. Atp1a2 contains two subunits, alpha and beta, with each having various isoforms and differential tissue distribution. In humans, mutations in ATP1A2 are associated with a rare form of hereditary migraines with aura known as familial hemiplegic migraine type II. Genetic studies in mice have revealed other neurological effects of Atp1a2 in mice including anxiety, fear, and learning and motor function disorders. This paper reviews the recent findings in the literature concerning Atp1a2. |
format | Online Article Text |
id | pubmed-3639839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-36398392013-05-06 Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models Gritz, Stephanie M Radcliffe, Richard A Hum Genomics Review Na(+)/K(+)-ATPase alpha 2 (Atp1a2) is an integral plasma membrane protein belonging to the P-type ATPase family that is responsible for maintaining the sodium (Na(+)) and potassium (K(+)) gradients across cellular membranes with hydrolysis of ATP. Atp1a2 contains two subunits, alpha and beta, with each having various isoforms and differential tissue distribution. In humans, mutations in ATP1A2 are associated with a rare form of hereditary migraines with aura known as familial hemiplegic migraine type II. Genetic studies in mice have revealed other neurological effects of Atp1a2 in mice including anxiety, fear, and learning and motor function disorders. This paper reviews the recent findings in the literature concerning Atp1a2. BioMed Central 2013-04-05 /pmc/articles/PMC3639839/ /pubmed/23561701 http://dx.doi.org/10.1186/1479-7364-7-8 Text en Copyright © 2013 Gritz and Radcliffe; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Gritz, Stephanie M Radcliffe, Richard A Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models |
title | Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models |
title_full | Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models |
title_fullStr | Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models |
title_full_unstemmed | Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models |
title_short | Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models |
title_sort | genetic effects of atp1a2 in familial hemiplegic migraine type ii and animal models |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639839/ https://www.ncbi.nlm.nih.gov/pubmed/23561701 http://dx.doi.org/10.1186/1479-7364-7-8 |
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