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Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models

Na(+)/K(+)-ATPase alpha 2 (Atp1a2) is an integral plasma membrane protein belonging to the P-type ATPase family that is responsible for maintaining the sodium (Na(+)) and potassium (K(+)) gradients across cellular membranes with hydrolysis of ATP. Atp1a2 contains two subunits, alpha and beta, with e...

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Autores principales: Gritz, Stephanie M, Radcliffe, Richard A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639839/
https://www.ncbi.nlm.nih.gov/pubmed/23561701
http://dx.doi.org/10.1186/1479-7364-7-8
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author Gritz, Stephanie M
Radcliffe, Richard A
author_facet Gritz, Stephanie M
Radcliffe, Richard A
author_sort Gritz, Stephanie M
collection PubMed
description Na(+)/K(+)-ATPase alpha 2 (Atp1a2) is an integral plasma membrane protein belonging to the P-type ATPase family that is responsible for maintaining the sodium (Na(+)) and potassium (K(+)) gradients across cellular membranes with hydrolysis of ATP. Atp1a2 contains two subunits, alpha and beta, with each having various isoforms and differential tissue distribution. In humans, mutations in ATP1A2 are associated with a rare form of hereditary migraines with aura known as familial hemiplegic migraine type II. Genetic studies in mice have revealed other neurological effects of Atp1a2 in mice including anxiety, fear, and learning and motor function disorders. This paper reviews the recent findings in the literature concerning Atp1a2.
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spelling pubmed-36398392013-05-06 Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models Gritz, Stephanie M Radcliffe, Richard A Hum Genomics Review Na(+)/K(+)-ATPase alpha 2 (Atp1a2) is an integral plasma membrane protein belonging to the P-type ATPase family that is responsible for maintaining the sodium (Na(+)) and potassium (K(+)) gradients across cellular membranes with hydrolysis of ATP. Atp1a2 contains two subunits, alpha and beta, with each having various isoforms and differential tissue distribution. In humans, mutations in ATP1A2 are associated with a rare form of hereditary migraines with aura known as familial hemiplegic migraine type II. Genetic studies in mice have revealed other neurological effects of Atp1a2 in mice including anxiety, fear, and learning and motor function disorders. This paper reviews the recent findings in the literature concerning Atp1a2. BioMed Central 2013-04-05 /pmc/articles/PMC3639839/ /pubmed/23561701 http://dx.doi.org/10.1186/1479-7364-7-8 Text en Copyright © 2013 Gritz and Radcliffe; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Gritz, Stephanie M
Radcliffe, Richard A
Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models
title Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models
title_full Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models
title_fullStr Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models
title_full_unstemmed Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models
title_short Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models
title_sort genetic effects of atp1a2 in familial hemiplegic migraine type ii and animal models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639839/
https://www.ncbi.nlm.nih.gov/pubmed/23561701
http://dx.doi.org/10.1186/1479-7364-7-8
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