Inhibition of p38MAPK and CD137 signaling reduce dengue virus-induced TNF-α secretion and apoptosis

BACKGROUND: Hepatic injury in dengue virus (DENV) infection is authenticated by hepatomegaly and an upsurge in transaminase levels. DENV replicates in hepatocytes and causes hepatocyte apoptosis both in vitro and in vivo. Understanding the molecular mechanisms of DENV-induced hepatic injury could fa...

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Detalles Bibliográficos
Autores principales: Nagila, Amar, Netsawang, Janjuree, Suttitheptumrong, Aroonroong, Morchang, Atthapan, Khunchai, Sasiprapa, Srisawat, Chatchawan, Puttikhunt, Chunya, Noisakran, Sansanee, Yenchitsomanus, Pa-thai, Limjindaporn, Thawornchai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639879/
https://www.ncbi.nlm.nih.gov/pubmed/23557259
http://dx.doi.org/10.1186/1743-422X-10-105

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