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Aggressive neuroblastomas have high p110alpha but low p110delta and p55alpha/p50alpha protein levels compared to low stage neuroblastomas

BACKGROUND: The phosphoinositide 3-kinase (PI3K)/Akt pathway is involved in neuroblastoma development where Akt/PKB activation is associated with poor prognosis. PI3K activity subsequently activates Akt/PKB, and as mutations of PI3K are rare in neuroblastoma and high levels of PI3K subunit p110delta...

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Detalles Bibliográficos
Autores principales:	Fransson, Susanne, Kogner, Per, Martinsson, Tommy, Ejeskär, Katarina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3639884/ https://www.ncbi.nlm.nih.gov/pubmed/23597230 http://dx.doi.org/10.1186/1750-2187-8-4

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