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Rapamycin Inhibits IGF-1-Mediated Up-Regulation of MDM2 and Sensitizes Cancer Cells to Chemotherapy

The Murine Double Minute 2 (MDM2) protein is a key regulator of cell proliferation and apoptosis that acts primarily by inhibiting the p53 tumor suppressor. Similarly, the PI3-Kinase (PI3K)/AKT pathway is critical for growth factor-mediated cell survival. Additionally, it has been reported that AKT...

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Detalles Bibliográficos
Autores principales:	Du, Wei, Yi, Yong, Zhang, Haibo, Bergholz, Johann, Wu, Junfeng, Ying, Haoqiang, Zhang, Yujun, Xiao, Zhi-Xiong Jim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640086/ https://www.ncbi.nlm.nih.gov/pubmed/23638184 http://dx.doi.org/10.1371/journal.pone.0063179

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