Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris

A new thiazolyl peptide, kocurin (1), was isolated from culture broths of a marine-derived Kocuria palustris. Its structural elucidation was accomplished using a combination of spectroscopic and chemical methods, including HRMS, extensive 1D and 2D NMR analysis, MS/MS fragmentation, and chemical deg...

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Autores principales: Martín, Jesús, Sousa, Thiciana da S., Crespo, Gloria, Palomo, Sara, González, Ignacio, Tormo, José R., de la Cruz, Mercedes, Anderson, Matthew, Hill, Russell T., Vicente, Francisca, Genilloud, Olga, Reyes, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2013
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640387/
https://www.ncbi.nlm.nih.gov/pubmed/23380989
http://dx.doi.org/10.3390/md11020387
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author Martín, Jesús
Sousa, Thiciana da S.
Crespo, Gloria
Palomo, Sara
González, Ignacio
Tormo, José R.
de la Cruz, Mercedes
Anderson, Matthew
Hill, Russell T.
Vicente, Francisca
Genilloud, Olga
Reyes, Fernando
author_facet Martín, Jesús
Sousa, Thiciana da S.
Crespo, Gloria
Palomo, Sara
González, Ignacio
Tormo, José R.
de la Cruz, Mercedes
Anderson, Matthew
Hill, Russell T.
Vicente, Francisca
Genilloud, Olga
Reyes, Fernando
author_sort Martín, Jesús
collection PubMed
description A new thiazolyl peptide, kocurin (1), was isolated from culture broths of a marine-derived Kocuria palustris. Its structural elucidation was accomplished using a combination of spectroscopic and chemical methods, including HRMS, extensive 1D and 2D NMR analysis, MS/MS fragmentation, and chemical degradation and Marfey’s analysis of the resulting amino acid residues. The structure herein reported corrects that previously assigned to PM181104 (3). Kocurin displayed activity against methicillin-resistant Staphylococcus aureus (MRSA), with MIC values in the submicromolar range.
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spelling pubmed-36403872013-05-02 Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris Martín, Jesús Sousa, Thiciana da S. Crespo, Gloria Palomo, Sara González, Ignacio Tormo, José R. de la Cruz, Mercedes Anderson, Matthew Hill, Russell T. Vicente, Francisca Genilloud, Olga Reyes, Fernando Mar Drugs Article A new thiazolyl peptide, kocurin (1), was isolated from culture broths of a marine-derived Kocuria palustris. Its structural elucidation was accomplished using a combination of spectroscopic and chemical methods, including HRMS, extensive 1D and 2D NMR analysis, MS/MS fragmentation, and chemical degradation and Marfey’s analysis of the resulting amino acid residues. The structure herein reported corrects that previously assigned to PM181104 (3). Kocurin displayed activity against methicillin-resistant Staphylococcus aureus (MRSA), with MIC values in the submicromolar range. MDPI 2013-02-04 /pmc/articles/PMC3640387/ /pubmed/23380989 http://dx.doi.org/10.3390/md11020387 Text en © 2013 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Martín, Jesús
Sousa, Thiciana da S.
Crespo, Gloria
Palomo, Sara
González, Ignacio
Tormo, José R.
de la Cruz, Mercedes
Anderson, Matthew
Hill, Russell T.
Vicente, Francisca
Genilloud, Olga
Reyes, Fernando
Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris
title Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris
title_full Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris
title_fullStr Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris
title_full_unstemmed Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris
title_short Kocurin, the True Structure of PM181104, an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Thiazolyl Peptide from the Marine-Derived Bacterium Kocuria palustris
title_sort kocurin, the true structure of pm181104, an anti-methicillin-resistant staphylococcus aureus (mrsa) thiazolyl peptide from the marine-derived bacterium kocuria palustris
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3640387/
https://www.ncbi.nlm.nih.gov/pubmed/23380989
http://dx.doi.org/10.3390/md11020387
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